Guanshen Cui
Chinese Academy of Sciences
14 Papers
Guanshen Cui is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Biology & Regeneration (biology). The author has an hindex of 5, co-authored 7 publications. Previous affiliations of Guanshen Cui include Beijing Institute of Genomics.
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Papers
Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma
Peng Junya,Bao-Fa Sun,Chuanyuan Chen,Chuanyuan Chen,Jia-Yi Zhou,Jia-Yi Zhou,Yu-Sheng Chen,Yu-Sheng Chen,Chen Hao,Liu Lulu,Huang Dan,Jialin Jiang,Guanshen Cui,Guanshen Cui,Ying Yang,Ying Yang,Wenze Wang,Dan Guo,Menghua Dai,Junchao Guo,Taiping Zhang,Quan Liao,Yi Liu,Yong-Liang Zhao,Yong-Liang Zhao,Dali Han,Dali Han,Yupei Zhao,Yupei Zhao,Yun-Gui Yang,Yun-Gui Yang,Wenming Wu +31 more
TL;DR: The transcriptomic atlas provided a valuable resource for deciphering the intra-tumoral heterogeneity in PDAC and uncovered a connection between tumor intrinsic transcriptional state and T cell activation, suggesting potential biomarkers for anticancer treatment such as targeted therapy and immunotherapy.
METTL3-mediated m6A modification is required for cerebellar development.
Chenxin Wang,Guanshen Cui,Guanshen Cui,Xiuying Liu,Kai Xu,Meng Wang,Xin-Xin Zhang,Liyuan Jiang,Ang Li,Ang Li,Ying Yang,Weiyi Lai,Bao-Fa Sun,Bao-Fa Sun,Guibin Jiang,Hailin Wang,Wei-Min Tong,Wei Li,Xiu-Jie Wang,Yun-Gui Yang,Yun-Gui Yang,Qi Zhou +21 more
TL;DR: It is shown that specific inactivation of Mettl3 in mouse nervous system causes severe developmental defects in the brain, and a critical role of METTL3-mediated m6A in regulating the development of mammalian cerebellum is revealed.
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N6-methyladenosine RNA modification suppresses antiviral innate sensing pathways via reshaping double-stranded RNA.
Weinan Qiu,Qingyang Zhang,Rui Zhang,Yangxu Lu,Xin Wang,Huabin Tian,Ying Yang,Zijuan Gu,Yanan Gao,Xin Yang,Guanshen Cui,Bao-Fa Sun,Yanan Peng,Hongyu Deng,Hua Peng,Angang Yang,Yun-Gui Yang,Pengyuan Yang,Pengyuan Yang +18 more
TL;DR: In this paper, the m6A methyltransferase METTL3 translocates into the cytoplasm to increase m6a modification on virus-derived transcripts and decrease viral dsRNA formation, thereby reducing virus-sensing efficacy by RIG-I and MDA5 and dampening antiviral immune signaling.
Spatiotemporal transcriptomic atlas reveals the dynamic characteristics and key regulators of planarian regeneration
Guanshen Cui,Kangning Dong,Jia-Yi Zhou,Qunlun Shen,Yongliang Zhao,Ying Yang,Shihua Zhang,Yun-Gui Yang +7 more
TL;DR: In this paper , a comprehensive 3D spatiotemporal transcriptomic landscape of planarian regeneration is presented, which provides a powerful tool for deciphering regeneration and identifying homeostasis-related genes.
An insight into planarian regeneration
TL;DR: This review summarizes the recent advances about the importance genetic and molecular mechanisms for regeneration control on various tissues in planarian and describes how these mechanisms are regulated by diverse mechanisms.
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