Gordon C. Weir
Harvard University
370 Papers
4.7K Citations
Gordon C. Weir is an academic researcher from Harvard University. The author has contributed to research in topics: Insulin & Transplantation. The author has an hindex of 99, co-authored 367 publications. Previous affiliations of Gordon C. Weir include Tufts Medical Center & Albert Einstein College of Medicine.
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Papers
Induced pluripotent stem cells generated without viral integration
Matthias Stadtfeld,Masaki Nagaya,Masaki Nagaya,Jochen Utikal,Gordon C. Weir,Gordon C. Weir,Konrad Hochedlinger +6 more
TL;DR: This work generated mouse induced pluripotent stem cells from fibroblasts and liver cells by using nonintegrating adenoviruses transiently expressing Oct4, Sox2, Klf4, and c-Myc, providing strong evidence that insertional mutagenesis is not required for in vitro reprogramming.
1.8K
Five Stages of Evolving Beta-Cell Dysfunction During Progression to Diabetes
Gordon C. Weir,Susan Bonner-Weir +1 more
TL;DR: Five stages in the progression of diabetes are proposed, each of which is characterized by different changes in beta-cell mass, phenotype, and function, which provides insight into the pathophysiology of both progression and remission of diabetes.
1.1K
Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas.
TL;DR: It is reported that a novel glucagon-like peptide, co-encoded with glucagon in the glucagon gene is a potent insulinotropic factor, and suggests that GLP-I(7-37) participates in the physiological regulation of insulin secretion.
Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus
TL;DR: It is shown here that human amylin is toxic to insulin-producing β-cells of the adult pancreas of rats and humans, and the mechanism of cell death involves RNA and protein synthesis and is characterized by plasma membrane blebbing, chromatin condensation and DNA fragmentation, indicating that amyl in induces islet cell apoptosis.
873
Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates
Omid Veiseh,Joshua C. Doloff,Minglin Ma,Arturo J. Vegas,Hok Hei Tam,Andrew Bader,Jie Li,Erin Langan,Jeffrey Wyckoff,Whitney S. Loo,Siddharth Jhunjhunwala,Alan Chiu,Sean M. Siebert,Katherine Tang,Jennifer Hollister-Lock,Stephanie Aresta-Dasilva,Matthew A. Bochenek,Joshua E. Mendoza-Elias,Yong Wang,Merigeng Qi,Danya M. Lavin,Michael Chen,Nimit Dholakia,Raj Thakrar,Igor Lacík,Gordon C. Weir,Jose Oberholzer,Dale L. Greiner,Robert Langer,Daniel G. Anderson +29 more
TL;DR: In this paper, a broad variety of material classes significantly abrogate foreign body reactions and fibrosis in rodent and non-human primates when the spheres are larger than 1.5 mm in diameter.