Gianluca Ursini
Johns Hopkins University
54 Papers
184 Citations
Gianluca Ursini is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Schizophrenia & Prefrontal cortex. The author has an hindex of 20, co-authored 47 publications. Previous affiliations of Gianluca Ursini include Johns Hopkins University School of Medicine & Istituto Italiano di Tecnologia.
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Papers
Modeling a Genetic Risk for Schizophrenia in iPSCs and Mice Reveals Neural Stem Cell Deficits Associated with Adherens Junctions and Polarity
Ki Jun Yoon,Ha Nam Nguyen,Gianluca Ursini,Fengyu Zhang,Namshik Kim,Zhexing Wen,Georgia Makri,David W. Nauen,Joo Heon Shin,Youngbin Park,Raeeun Chung,Eva Pekle,Ce Zhang,Maxwell Towe,Syed Mohammed Qasim Hussaini,Yohan Lee,Dan Rujescu,David St Clair,Joel E. Kleinman,Thomas M. Hyde,Gregory L. Krauss,Kimberly M. Christian,Judith L. Rapoport,Daniel R. Weinberger,Hongjun Song,Guo Li Ming +25 more
TL;DR: In insight into how CYFIP1 regulates neural stem cell function and may contribute to the susceptibility of neuropsychiatric disorders, targeted human genetic association analyses revealed an epistatic interaction between CYFip1 and WAVE signaling mediator ACTR2 and risk for schizophrenia.
252
Stress-Related Methylation of the Catechol-O-Methyltransferase Val158 Allele Predicts Human Prefrontal Cognition and Activity
Gianluca Ursini,Valentina Bollati,Leonardo Fazio,Annamaria Porcelli,Luisa Iacovelli,Assia Catalani,Lorenzo Sinibaldi,Barbara Gelao,Raffaella Romano,Antonio Rampino,Paolo Taurisano,Marina Mancini,Annabella Di Giorgio,Annabella Di Giorgio,Teresa Popolizio,Andrea A. Baccarelli,Andrea A. Baccarelli,Antonio De Blasi,Giuseppe Blasi,Alessandro Bertolino,Alessandro Bertolino +20 more
TL;DR: The relationship of methylation of the COMT Val158 allele with stress, gene expression, WM performance, and related brain activity suggests that stress-related methylation is associated with silencing of the gene, which partially compensates the physiological role of the high-activity Val allele in prefrontal cognition and activity.
198
Longitudinal analyses of the DNA methylome in deployed military servicemen identify susceptibility loci for post-traumatic stress disorder
Bart P. F. Rutten,Eric Vermetten,Eric Vermetten,Eric Vermetten,Christiaan H. Vinkers,Gianluca Ursini,Nikolaos P. Daskalakis,Ehsan Pishva,L. De Nijs,Lotte C Houtepen,Lars M. T. Eijssen,Andrew E. Jaffe,Gunter Kenis,Wolfgang Viechtbauer,D.L.A. van den Hove,D.L.A. van den Hove,K. Schraut,Klaus-Peter Lesch,Klaus-Peter Lesch,Joel E. Kleinman,Thomas M. Hyde,D.R. Weinberger,Leonard C. Schalkwyk,Katie Lunnon,Jonathan Mill,Hagit Cohen,Rachel Yehuda,Dewleen G. Baker,Dewleen G. Baker,Adam X. Maihofer,Adam X. Maihofer,Caroline M. Nievergelt,Caroline M. Nievergelt,Elbert Geuze,Elbert Geuze,Marco P. Boks +35 more
TL;DR: This study pinpoints three novel genomic regions where longitudinal decreases in DNA methylation across the period of exposure to combat trauma marks susceptibility for PTSD.
Genetically Determined Interaction between the Dopamine Transporter and the D2 Receptor on Prefronto-Striatal Activity and Volume in Humans
Alessandro Bertolino,Leonardo Fazio,Annabella Di Giorgio,Giuseppe Blasi,Raffaella Romano,Paolo Taurisano,Grazia Caforio,Lorenzo Sinibaldi,Lorenzo Sinibaldi,Gianluca Ursini,Gianluca Ursini,Teresa Popolizio,Emanuele Tirotta,Audrey C. Papp,Bruno Dallapiccola,Bruno Dallapiccola,Emiliana Borrelli,Wolfgang Sadee +17 more
TL;DR: The results demonstrate that the interaction between genetic variants in DRD2 and DAT critically modulates the nonlinear relationship between dopamine and neuronal activity during memory processing.
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Genetically determined measures of striatal D2 signaling predict prefrontal activity during working memory performance
Alessandro Bertolino,Alessandro Bertolino,Paolo Taurisano,N. Pisciotta,Giuseppe Blasi,Leonardo Fazio,Leonardo Fazio,Raffaella Romano,Barbara Gelao,Luciana Lo Bianco,Madia Lozupone,Annabella Di Giorgio,Grazia Caforio,Fabio Sambataro,Artor Niccoli-Asabella,Audrey C. Papp,Gianluca Ursini,Lorenzo Sinibaldi,Teresa Popolizio,Wolfgang Sadee,Giuseppe Rubini +20 more
TL;DR: It is demonstrated that this functional SNP within DRD2 predicts striatal binding of the two radiotracers to dopamine transporters and D2 receptors as well as the correlation between striatal D2 signaling with prefrontal cortex activity during performance of a working memory task.