Georg Meisl
University of Cambridge
137 Papers
201 Citations
Georg Meisl is an academic researcher from University of Cambridge. The author has contributed to research in topics: Protein aggregation & Chemistry. The author has an hindex of 30, co-authored 102 publications. Previous affiliations of Georg Meisl include Massachusetts Institute of Technology & Ikerbasque.
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Papers
Molecular mechanisms of protein aggregation from global fitting of kinetic models
Georg Meisl,Julius B. Kirkegaard,Paolo Arosio,Thomas C. T. Michaels,Michele Vendruscolo,Christopher M. Dobson,Sara Linse,Tuomas P. J. Knowles +7 more
TL;DR: This work describes a framework, using quantitative kinetic assays and global fitting, to determine and to verify a molecular mechanism for aggregation reactions that is compatible with experimental kinetic data and provides an online platform that enables robust global analysis of kinetic data without the need for extensive programming or detailed mathematical knowledge.
663
Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation
Céline Galvagnion,Alexander K. Buell,Georg Meisl,Thomas C. T. Michaels,Michele Vendruscolo,Tuomas P. J. Knowles,Christopher M. Dobson +6 more
TL;DR: The results reveal the key role that membrane interactions can have in triggering conversion of α-syn from its soluble state to the aggregated state that is associated with neurodegeneration and to its associated disease states.
621
Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides
Georg Meisl,Xiaoting Yang,Erik Hellstrand,Birgitta Frohm,Julius B. Kirkegaard,Samuel I. A. Cohen,Christopher M. Dobson,Sara Linse,Tuomas P. J. Knowles +8 more
TL;DR: This analysis sheds light on the microscopic determinants of the aggregation behavior of the principal forms of Aβ and outlines a general approach toward achieving an understanding at the molecular level of the aberrant deposition of insoluble peptides in neurodegenerative disorders.
475
Secondary nucleation in amyloid formation.
Mattias Törnquist,Thomas C. T. Michaels,Thomas C. T. Michaels,Kalyani Sanagavarapu,Xiaoting Yang,Georg Meisl,Samuel I. A. Cohen,Tuomas P. J. Knowles,Sara Linse +8 more
TL;DR: A short overview of the background and recent results regarding secondary nucleation of amyloid-forming peptides and proteins, focusing in particular on the amyloids β peptide (Aβ) from Alzheimer's disease, and review experiments aimed at finding interaction partners of oligomers generated by secondaryucleation in an ongoing aggregation process.
384
Mutations associated with familial Parkinson’s disease alter the initiation and amplification steps of α-synuclein aggregation
Patrick Flagmeier,Georg Meisl,Michele Vendruscolo,Tuomas P. J. Knowles,Christopher M. Dobson,Alexander K. Buell,Céline Galvagnion +6 more
TL;DR: It is found that lipid-induced fibril production and surface catalyzed fibrils amplification are the processes most strongly affected by these mutations and show that familial mutations can induce dramatic changes in the crucial processes thought to be associated with the initiation and spreading of the aggregation of α-synuclein.
307