Franziska Graf
Helmholtz-Zentrum Dresden-Rossendorf
5 Papers
7 Citations
Franziska Graf is an academic researcher from Helmholtz-Zentrum Dresden-Rossendorf. The author has contributed to research in topics: Cell cycle & Cyclin. The author has an hindex of 5, co-authored 5 publications.
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Papers
Cell Cycle Regulating Kinase Cdk4 as a Potential Target for Tumor Cell Treatment and Tumor Imaging
TL;DR: The data demonstrate a defined and specific inhibition of tumor cell proliferation through CKIA and CKIB by inhibition of the Cdk4/pRb/E2F pathway emphasizing potential therapeutic benefit of CKIAand CKIB.
Cyclin-dependent kinase 4/6 (cdk4/6) inhibitors: perspectives in cancer therapy and imaging.
TL;DR: The potential of Cdk4/6 inhibitors, particularly, pyrido[2,3-d]pyrimidine derivatives, as both anti-cancer drugs and 124I- and 18F-radiolabeled tracers for cancer imaging using positron emission tomography is discussed.
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Radiosynthesis and radiopharmacological evaluation of cyclin-dependent kinase 4 (Cdk4) inhibitors.
TL;DR: The design, synthesis and radiopharmacological evaluation of two (124)I-labeled Cdk4 inhibitors as potential radiotracers for imaging of Cdk 4 in vivo are described and shown to be promising molecular probes for imaging cell proliferation processes and tumor visualization by PET.
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Cyclin-Dependent Kinases (Cdk) as Targets for Cancer Therapy and Imaging
Franziska Graf,Frank Wuest,Jens Pietzsch +2 more
- 21 Nov 2011
TL;DR: Aberration in proliferation and consequently in cell cycle control is a common aspect in carcinogenesis and as master cell cycle regulating proteins in all eukaryotic cells the Cyclindependent kinases (Cdk) were identified in the 1970s and 1980s.
Radiosynthesis of a 18F-labeled 2,3-diarylsubstituted indole via McMurry coupling for functional characterization of cyclooxygenase-2 (COX-2) in vitro and in vivo
Torsten Kniess,Markus Laube,Ralf Bergmann,Fabian Sehn,Franziska Graf,Joerg Steinbach,Frank Wuest,Jens Pietzsch +7 more
TL;DR: The radiosynthesis of 3-(4-[(18)F]fluorophenyl)-2-(4-methylsulfonylphenyl)-1H-indole [(18]F]-3 as potential PET radiotracer for functional characterization of cyclooxygenase-2 (COX-2) in vitro and in vivo is described.