Fei-Yan Pan
Nanjing Normal University
14 Papers
61 Citations
Fei-Yan Pan is an academic researcher from Nanjing Normal University. The author has contributed to research in topics: MAPK/ERK pathway & Signal transduction. The author has an hindex of 10, co-authored 14 publications. Previous affiliations of Fei-Yan Pan include National Resource Center & Nanjing University.
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Papers
Egr-1 decreases adipocyte insulin sensitivity by tilting PI3K/Akt and MAPK signal balance in mice.
Xiao Yu,Xiao Yu,Ning Shen,Mingliang Zhang,Fei-Yan Pan,Chen Wang,Weiping Jia,Chang Liu,Qian Gao,Xiang Gao,Bin Xue,Chao-Jun Li,Chao-Jun Li +12 more
TL;DR: It is shown that an early response transcription factor Egr‐1 could tilt the signalling balance by blocking PI3K/Akt signalling through PTEN and augmenting Erk/MAPK signalling through GGPPS, resulting in insulin resistance in adipocytes.
The alteration of protein prenylation induces cardiomyocyte hypertrophy through Rheb-mTORC1 signalling and leads to chronic heart failure.
Na Xu,Shan Guan,Zhong Chen,Yang Yu,Jun Xie,Fei-Yan Pan,Ning-Wei Zhao,Li Liu,Zhongzhou Yang,Xiang Gao,Biao Xu,Chao-Jun Li +11 more
TL;DR: It is reported that protein prenylation, a lipidic modification of G proteins that facilitates their association with the cell membrane, might control the process of cardiomyocyte hypertrophy and may provide a new molecular target for hypertrophic heart disease clinical therapy.
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Intracellular Trafficking of Histone Deacetylase 4 Regulates Long-Term Memory Formation
Wen-Han Wang,Li-Cheng Cheng,Fei-Yan Pan,Fei-Yan Pan,Bin Xue,Da-Yong Wang,Zhong Chen,Chao-Jun Li,Chao-Jun Li +8 more
TL;DR: The hypothesis was that shuttling of Class II HDACs, such as HDAC4, between the nucleus and cytoplasm is critical for its function, and results support this hypothesis.
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GGPPS, a New EGR-1 Target Gene, Reactivates ERK 1/2 Signaling through Increasing Ras Prenylation
Ning Shen,Yue Shao,Shan-Shan Lai,Long Qiao,Run-Lin Yang,Bin Xue,Fei-Yan Pan,Hua-Qun Chen,Chao-Jun Li,Chao-Jun Li,Chao-Jun Li +10 more
TL;DR: Evidence is provided that EGR-1 activation can also reactivate ERK 1/2 mitogen activated-protein kinase through a positive feedback loop through its target gene (geranylgeranyl diphosphate synthase) GGPPS, which might affect cigarette smoke-related lung pathological processes.
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Polo-like kinase 1 regulates mitotic arrest after UV irradiation through dephosphorylation of p53 and inducing p53 degradation.
Jie Chen,Gu Dai,Gu Dai,Yi-Qian Wang,Sheng Wang,Fei-Yan Pan,Bin Xue,Dong-Hong Zhao,Chao-Jun Li,Chao-Jun Li +9 more
TL;DR: It is found that UV treatment leads HEK293 cells to inverse changes of Plk1 and p53, and hypothesize that PlK1 and Cdc25C participate in recovery the mitotic arrest through binding to the different domain of p53.
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