Eva Lenfert
University of Hamburg
4 Papers
14 Citations
Eva Lenfert is an academic researcher from University of Hamburg. The author has contributed to research in topics: Mesenchymal stem cell & Mammary tumor. The author has an hindex of 4, co-authored 4 publications. Previous affiliations of Eva Lenfert include Heinrich Pette Institute.
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Papers
CEACAM1 controls the EMT switch in murine mammary carcinoma in vitro and in vivo
Wegwitz Florian,Eva Lenfert,Daniela Gerstel,Lena von Ehrenstein,Julia Einhoff,Geske Schmidt,Matthew Logsdon,Johanna M. Brandner,Gisa Tiegs,Nicole Beauchemin,Christoph Wagener,Wolfgang Deppert,Andrea Kristina Horst +12 more
TL;DR: Survival analyses of human mammary carcinoma patients corroborated these data, indicating that CEACAM1 is a prognostic marker for breast cancer survival.
Chemotherapy of WAP-T mouse mammary carcinomas aggravates tumor phenotype and enhances tumor cell dissemination.
TL;DR: Results suggest that tumor cells that underwent epithelial‐mesenchymal transition and/or exhibit stem‐cell‐like properties are difficult to eliminate using one round of CAF chemotherapy, thereby enabling the development and preclinical evaluation of novel therapeutic strategies to target mammary carcinomas.
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Mutant p53 promotes epithelial-mesenchymal plasticity and enhances metastasis in mammary carcinomas of WAP-T mice.
Eva Lenfert,Eva Lenfert,Claudia Maenz,Claudia Maenz,Christina Heinlein,Katharina Jannasch,Udo Schumacher,Klaus Pantel,Genrich V. Tolstonog,Genrich V. Tolstonog,Wolfgang Deppert,Wolfgang Deppert,Florian Wegwitz,Florian Wegwitz,Florian Wegwitz +14 more
TL;DR: Induction of an EMT gene signature by mutp53 in bitransgenic tumors primarily promotes tumor cell plasticity, that is, the probability of tumor cells to undergo EMT processes under appropriate stimuli, thereby possibly increasing their potential to disseminate and metastasize.
Epithelial-mesenchymal plasticity is a decisive feature for the metastatic outgrowth of disseminated WAP-T mouse mammary carcinoma cells.
Claudia Maenz,Claudia Maenz,Eva Lenfert,Eva Lenfert,Klaus Pantel,Udo Schumacher,Wolfgang Deppert,Wolfgang Deppert,Florian Wegwitz,Florian Wegwitz,Florian Wegwitz +10 more
TL;DR: The utility of the immune-competent transplantable mouse mammary tumor model to analyze factors influencing tumor cell dissemination and metastasis is demonstrated and it is suggested that the different metastatic capacity of G-2 and H8N8 cells is due to their different degrees of epithelial-mesenchymal plasticity, and thus the ability of the respective disseminated cells to revert from a “mesenchyal” to an “epithelial” differentiation state.