Esther Hoste
Ghent University
48 Papers
319 Citations
Esther Hoste is an academic researcher from Ghent University. The author has contributed to research in topics: Wound healing & Biology. The author has an hindex of 18, co-authored 36 publications. Previous affiliations of Esther Hoste include King's College London.
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Papers
Distinct fibroblast lineages determine dermal architecture in skin development and repair
Ryan R. Driskell,Ryan R. Driskell,Beate M. Lichtenberger,Beate M. Lichtenberger,Esther Hoste,Kai Kretzschmar,Kai Kretzschmar,Ben D. Simons,Marika Charalambous,Sacri R. Ferrón,Yann Herault,Guillaume Pavlovic,Anne C. Ferguson-Smith,Fiona M. Watt +13 more
TL;DR: It is shown, using transplantation assays and lineage tracing in mice, that the fibroblasts of skin connective tissue arise from two distinct lineages, which explains why wounding is linked to formation of ECM-rich scar tissue that lacks hair follicles.
1.1K
Epithelial stem cells, wound healing and cancer
TL;DR: Lineage tracing has now shown how stem cells are mobilized to repair skin wounds and how they contribute to skin tumour development, and suggest ways to harness stem cells for wound repair while minimizing cancer risk.
453
Caspase-14 Is Required for Filaggrin Degradation to Natural Moisturizing Factors in the Skin
Esther Hoste,Patrick M.J.H. Kemperman,Michael Devos,Geertrui Denecker,Sanja Kezic,Nico L. H. Yau,Barbara Gilbert,Saskia Lippens,Philippe De Groote,Ria Roelandt,Petra Van Damme,Kris Gevaert,Richard B. Presland,Hidenari Takahara,Gerwin J. Puppels,Peter J. Caspers,Peter Vandenabeele,Wim Declercq +17 more
TL;DR: It is shown that the defective FLG degradation in caspase-14-deficient skin results in substantial reduction in the amount of NMFs, such as urocanic acid and pyrrolidone carboxylic acid.
206
A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation
Sofie Voet,Conor Mc Guire,Nora Hagemeyer,Arne Martens,Anna Schroeder,Peter Wieghofer,Peter Wieghofer,Carmen Daems,Ori Staszewski,Lieselotte Vande Walle,Marta Joana Costa Jordão,Mozes Sze,Hanna-Kaisa Vikkula,Delphine Demeestere,Griet Van Imschoot,Charlotte L. Scott,Esther Hoste,Amanda Gonçalves,Martin Guilliams,Saskia Lippens,Claude Libert,Roosmarijn E. Vandenbroucke,Ki-Wook Kim,Ki-Wook Kim,Steffen Jung,Zsuzsanna Callaerts-Vegh,Patrick Callaerts,Joris de Wit,Mohamed Lamkanfi,Marco Prinz,Geert van Loo +30 more
TL;DR: It is demonstrated that the nuclear factor kappa B (NF-κB) regulatory protein A20 is crucial in regulating microglia activation during CNS homeostasis and pathology and exacerbates multiple sclerosis-like disease.
203
Targeting SLC7A11 improves efferocytosis by dendritic cells and wound healing in diabetes
Sophia Maschalidi,Parul Mehrotra,Burcu Nur Keçeli,Hannah K L De Cleene,K. Lecomte,Renée Van der Cruyssen,Pauline Janssen,Jonathan J. Pinney,Geert van Loo,Dirk Elewaut,Ann Massie,Esther Hoste,Kodi S. Ravichandran +12 more
TL;DR: In this paper , the membrane transporter SLC7a11 acts as a molecular brake on efferocytosis, the process by which dying cells are removed, and that inhibiting SLC 7a11 function can accelerate wound healing.
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