Eric Guillemare
Centre national de la recherche scientifique
27 Papers
605 Citations
Eric Guillemare is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Potassium channel & Protein subunit. The author has an hindex of 20, co-authored 27 publications.
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Papers
K v LQT1 and IsK (minK) proteins associate to form the I KS cardiac potassium current
TL;DR: It is shown that KVLQT1 associates with IsK to form the channel underlying the IKS cardiac current, which is a target of class-Ill anti-arrhythmic drugs and is involved in the L QT1 syndrome.
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TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure.
Florian Lesage,Eric Guillemare,Michel Fink,Fabrice Duprat,Michel Lazdunski,Georges Romey,Jacques Barhanin +6 more
TL;DR: A weakly inward rectifying K+ channel, TWIK-1, has been isolated in Xenopus oocytes as discussed by the authors, which has four transmembrane domains and a unitary conductance of 34 pS and a kinetic behavior that is dependent on the membrane potential.
569
Molecular properties of neuronal G-protein-activated inwardly rectifying K^+ channels
Florian Lesage,Eric Guillemare,Michel Fink,Fabrice Duprat,Catherine Heurteaux,Michel Fosset,Georges Romey,Jacques Barhanin,Michel Lazdunski +8 more
TL;DR: Since the nonhydrolyzable ATP analog AMP-PCP is also active and since addition of kinases A and C as well as alkaline phosphatase does not modify the ATP effect, it is concluded that ATP hydrolysis is not required.
274
Dimerization of TWIK-1 K+ channel subunits via a disulfide bridge.
TL;DR: This work shows that TWIK‐1 subunits can self‐associate to give dimers containing an interchain disulfide bridge, the first example of a covalent association of functional subunits in voltage‐sensitive channels via a disulfides bridge.
186
Heterologous multimeric assembly is essential for K+ channel activity of neuronal and cardiac G-protein-activated inward rectifiers.
Duprat F,Florian Lesage,Eric Guillemare,Michel Fink,Jean-Philippe Hugnot,Joëlle Bigay,Michel Lazdunski,Georges Romey,Jacques Barhanin +8 more
TL;DR: It is shown that Xenopus expression of this new channel that is called GIRK4 does not produce an ATP-inhibitable activity with a pharmacological activation by pinacidil as previously described but instead a G-protein activated inward-rectifier.
158