27 Papers
76 Citations
Eric Duplan is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Parkin & Transcription factor. The author has an hindex of 14, co-authored 24 publications. Previous affiliations of Eric Duplan include Centre national de la recherche scientifique & University of Nice Sophia Antipolis.
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Papers
Hypoxia Up-regulates Prolyl Hydroxylase Activity A FEEDBACK MECHANSIM THAT LIMITS HIF-1 RESPONSES DURING REOXYGENATION
TL;DR: The results suggest that a hypoxic upregulation of PHD (presumably PHD-2) acts as a feedback mechanism to stop hypoxic responses in reoxygenated cells and it is proposed that proline hydroxylation might play a role in hypoxic preconditioning.
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Nuclear factor-κB regulates βAPP and β- and γ-secretases differently at physiological and supraphysiological Aβ concentrations.
Linda Chami,Virginie Buggia-Prevot,Eric Duplan,Dolores Delprete,Mounia Chami,Jean-François Peyron,Frédéric Checler +6 more
TL;DR: In this paper, the putative NF-κB-dependent modulation of all cellular participants in Aβ production, namely its precursor βAPP (β-amyloid precursor protein) and the β- and γ-secretases, were delineated.
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Nuclear p53-mediated repression of autophagy involves PINK1 transcriptional down-regulation.
Thomas Goiran,Eric Duplan,Lila Rouland,Wejdane El Manaa,Inger Lauritzen,Julie Dunys,Han You,Frédéric Checler,Cristine Alves da Costa +8 more
TL;DR: A novel pathway by which nuclear p53 can repress autophagy/mitophagy that could underlie important dysfunctions in both neurodegenerative and cancer diseases is unraveled.
ER-stress-associated functional link between Parkin and DJ-1 via a transcriptional cascade involving the tumor suppressor p53 and the spliced X-box binding protein XBP-1.
Eric Duplan,Emilie Giaime,Julien Viotti,Jean Sevalle,Olga Corti,Alexis Brice,Hiroyoshi Ariga,Ling Qi,Frédéric Checler,Cristine Alves da Costa +9 more
TL;DR: A mechanistic explanation for the increase in the unfolded protein response observed in PD pathology is provided, i.e. that it is due to a defect in parkin-associated control of DJ-1.
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The Endoplasmic Reticulum Stress/Unfolded Protein Response and Their Contributions to Parkinson's Disease Physiopathology
TL;DR: Insight is given on the ER and its functioning; the UPR signaling cascades; and the link between ER stress, UPR activation, and physiopathology of PD.
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