En-Ching Luo
University of California, San Diego
19 Papers
15 Citations
En-Ching Luo is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Biology & Interactome. The author has an hindex of 7, co-authored 12 publications. Previous affiliations of En-Ching Luo include National Taiwan University.
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Papers
Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules.
Sebastian Markmiller,Sahar Soltanieh,Kari L. Server,Raymond H. Mak,Wenhao Jin,Mark Y. Fang,En-Ching Luo,Florian Krach,Dejun Yang,Anindya Sen,Amit Fulzele,Jacob M. Wozniak,David Gonzalez,David Gonzalez,Mark W. Kankel,Fen-Biao Gao,Eric J. Bennett,Eric Lécuyer,Gene W. Yeo +18 more
TL;DR: Stress granules (SGs) are transient ribonucleoprotein (RNP) aggregates that form during cellular stress and are increasingly implicated in human neurodegeneration as mentioned in this paper.
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The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis
Bruno Di Stefano,En-Ching Luo,Chuck Haggerty,Stefan Aigner,Jocelyn Charlton,Justin Brumbaugh,Fei Ji,Inés Rabano Jiménez,Katie J. Clowers,Aaron J. Huebner,Kendell Clement,Kendell Clement,Inna Lipchina,Marit A.C. de Kort,Anthony Anselmo,John L. Pulice,Mattia F. M. Gerli,Hongcang Gu,Hongcang Gu,Steven P. Gygi,Ruslan I. Sadreyev,Alexander Meissner,Alexander Meissner,Alexander Meissner,Gene W. Yeo,Konrad Hochedlinger +25 more
TL;DR: In this paper, the RNA helicase DDX6 was found to influence the balance between self-renewal and differentiation in a context-dependent manner in adult stem cells.
120
G4C2 Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD.
Alyssa N. Coyne,Benjamin L. Zaepfel,Lindsey R. Hayes,Boris Fitchman,Yuval Salzberg,En-Ching Luo,Kelly Bowen,Hannah Trost,Stefan Aigner,Frank Rigo,Gene W. Yeo,Amnon Harel,Clive N. Svendsen,Dhruv Sareen,Jeffrey D. Rothstein +14 more
TL;DR: The data suggest that the expression of expanded C9orf72 ALS/FTD repeat RNA alone affects nuclear POM121 expression in the initiation of a pathological cascade affecting nucleoporin levels within neuronal nuclei and ultimately downstream neuronal survival.
120
AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation
Jeanine L. Van Nostrand,Kristina Hellberg,En-Ching Luo,Eric L. Van Nostrand,Alina Dayn,Jingting Yu,Maxim N. Shokhirev,Yelena Dayn,Gene W. Yeo,Reuben J. Shaw +9 more
TL;DR: The hepatic transcriptional response in mice on high-fat diet treated with metformin was largely ablated by AMPK deficiency under the conditions examined, indicating the essential role of this kinase and its targets in meetformin action in vivo.
MicroRNA-449a enhances radiosensitivity in CL1-0 lung adenocarcinoma cells.
Yi Jyun Liu,Yu Fen Lin,Yi Fan Chen,En-Ching Luo,Yuh Ping Sher,Mong-Hsun Tsai,Eric Y. Chuang,Liang-Chuan Lai +7 more
TL;DR: Overexpression of miR-449a in CL1-0 cells effectively increased irradiation-induced DNA damage and apoptosis, altered the cell cycle distribution and eventually led to sensitization of CL 1-0 to irradiation.