Emmanuel Chautard
University of Auvergne
40 Papers
117 Citations
Emmanuel Chautard is an academic researcher from University of Auvergne. The author has contributed to research in topics: Glioma & Medicine. The author has an hindex of 15, co-authored 35 publications. Previous affiliations of Emmanuel Chautard include French Institute of Health and Medical Research.
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Papers
Altering DNA Repair to Improve Radiation Therapy: Specific and Multiple Pathway Targeting
TL;DR: Recent advances in the development of novel inhibitors of DNA repair pathways in combination with RT are reviewed, including mimicking DNA double-strand breaks via small interfering DNA to bait the whole DNA repair machinery, leading to its global inhibition.
Pembrolizumab versus cetuximab concurrent with radiotherapy in patients with locally advanced squamous cell carcinoma of head and neck unfit for cisplatin (GORTEC 2015-01 PembroRad): a multicenter, randomized, phase II trial.
Yungan Tao,Julian Biau,X. Sun,Christian Sire,Laurent Martin,Marc Alfonsi,Jean-Briac Prévost,A. Modesto,Cedrik Lafond,Jean-Marc Tourani,J. Miroir,Marie-Christine Kaminsky,Alexandre Coutte,Xavier Liem,Emmanuel Chautard,Enora Vauléon,Franck Drouet,Amandine Ruffier,Jean-François Ramée,Gabriel Waksi,Adeline Péchery,Mathilde Wanneveich,Joël Guigay,Anne Auperin,J. Bourhis +24 more
TL;DR: In this article , the potential synergistic effect of pembrolizumab with radiotherapy (RT) compared with a standard-of-care (SOC) cetuximab-RT in patients with locally advanced-squamous cell carcinoma of head and neck (LA-SCCHN) was evaluated.
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Role of Akt in human malignant glioma: from oncogenesis to tumor aggressiveness
Emmanuel Chautard,Zangbéwendé Guy Ouédraogo,Zangbéwendé Guy Ouédraogo,Julian Biau,Julian Biau,Pierre Verrelle +5 more
TL;DR: The role of each isoform in malignant glioma that strengthens the current preclinical and clinical studies evaluating the impact of Akt pathway targeting in glioblastomas is explored.
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Second course of stereotactic radiosurgery for locally recurrent brain metastases: Safety and efficacy.
J. Moreau,Toufic Khalil,G. Dupic,Emmanuel Chautard,Jean-Jacques Lemaire,F. Magnier,V. Dedieu,Michel Lapeyre,Pierre Verrelle,Pierre Verrelle,Julian Biau +10 more
TL;DR: This treatment led to acceptable toxicities, especially for brain metastases smaller than 7cc, in the authors' selected cohort of patients with BM located outside critical structures, and a second course of SRS for locally recurrentbrain metastases showed encouraging rates of local control.
A Preclinical Study Combining the DNA Repair Inhibitor Dbait with Radiotherapy for the Treatment of Melanoma
Julian Biau,Flavien Devun,Wael Jdey,Ewa Kotula,Maria Quanz,Emmanuel Chautard,Mano Sayarath,Jian-Sheng Sun,Pierre Verrelle,Marie Dutreix +9 more
TL;DR: In this paper, the cytotoxic efficacy of Dbait in combination with RT was evaluated in vitro in SK28 and 501mel human melanoma cell lines, and the capacity of DT01 to enhance efficacy of "palliative" RT (10 × 3 Gy) or "radical" RT(20 × 3 gy), in an SK28 xenografted model.
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