Emma S. Winkler
Washington University in St. Louis
47 Papers
81 Citations
Emma S. Winkler is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Monoclonal antibody & Biology. The author has an hindex of 21, co-authored 43 publications.
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Papers
Potently neutralizing and protective human antibodies against SARS-CoV-2.
Seth J. Zost,Pavlo Gilchuk,James Brett Case,Elad Binshtein,Rita E. Chen,Joseph P. Nkolola,Alexandra Schäfer,Joseph X. Reidy,Andrew Trivette,Rachel S. Nargi,Rachel E. Sutton,Naveenchandra Suryadevara,David R. Martinez,Lauren E. Williamson,Elaine C. Chen,Taylor Jones,Samuel Day,Luke Myers,Ahmed O. Hassan,Natasha M. Kafai,Emma S. Winkler,Julie M. Fox,Swathi Shrihari,Benjamin K. Mueller,Jens Meiler,Jens Meiler,Abishek Chandrashekar,Noe B. Mercado,James J. Steinhardt,Kuishu Ren,Yueh-Ming Loo,Nicole L. Kallewaard,Broc T. McCune,Shamus P. Keeler,Michael J. Holtzman,Dan H. Barouch,Lisa E. Gralinski,Ralph S. Baric,Larissa B. Thackray,Michael S. Diamond,Robert H. Carnahan,James E. Crowe +41 more
TL;DR: An analysis identifies human monoclonal antibodies that potently neutralize wild-type SARS-CoV-2 and protect animals from disease, including two that synergize in a cocktail, suggesting that these could be candidates for use as therapeutic agents for the treatment of COVID-19 in humans.
Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies.
Rita E. Chen,Xianwen Zhang,James Brett Case,Emma S. Winkler,Yang Liu,Laura A. VanBlargan,Jianying Liu,John M. Errico,Xuping Xie,Naveenchandra Suryadevara,Pavlo Gilchuk,Seth J. Zost,Stephen Tahan,Lindsay Droit,Jackson S. Turner,Wooseob Kim,Aaron J. Schmitz,Mahima Thapa,David Wang,Adrianus C. M. Boon,Rachel M. Presti,Jane A. O’Halloran,Alfred H.J. Kim,Parakkal Deepak,Dora Pinto,Daved H. Fremont,James E. Crowe,Davide Corti,Herbert W. Virgin,Herbert W. Virgin,Ali H. Ellebedy,Pei Yong Shi,Michael S. Diamond +32 more
TL;DR: In this article, using monoclonal antibodies (mAbs), animal immune sera, human convalescent sera and human sera from recipients of the BNT162b2 mRNA vaccine, the authors report the impact on antibody neutralization of a panel of authentic SARS-CoV-2 variants including a B.1.7 isolate, chimeric strains with South African or Brazilian spike genes and isogenic recombinant viral variants.
SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function.
Emma S. Winkler,Adam L. Bailey,Natasha M. Kafai,Sharmila Nair,Broc T. McCune,Jinsheng Yu,Julie M. Fox,Rita E. Chen,James T. Earnest,Shamus P. Keeler,Jon H. Ritter,Liang I. Kang,Sarah Dort,Annette Robichaud,Richard D. Head,Michael J. Holtzman,Michael S. Diamond +16 more
TL;DR: The transgenic mice expressing the human angiotensin I-converting enzyme 2 (ACE2) receptor driven by the cytokeratin-18 (K18) gene promoter are evaluated as a model of SARS-CoV-2 infection to define the basis of lung disease and test immune and antiviral-based countermeasures.
Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis.
Bryan A. Johnson,Xuping Xie,Adam L. Bailey,Birte Kalveram,Kumari G. Lokugamage,Antonio E. Muruato,Jing Zou,Xianwen Zhang,Terry L. Juelich,Jennifer K. Smith,Lihong Zhang,Nathen E. Bopp,Craig Schindewolf,Michelle N Vu,Abigail Vanderheiden,Emma S. Winkler,Daniele M. Swetnam,Jessica A. Plante,Patricia V. Aguilar,Kenneth S. Plante,Vsevolod L. Popov,Benhur Lee,Scott C. Weaver,Mehul S. Suthar,Andrew Routh,Ping Ren,Zhiqiang Ku,Zhiqiang An,Kari Debbink,Michael S. Diamond,Pei Yong Shi,Alexander N. Freiberg,Vineet D. Menachery +32 more
TL;DR: In this paper, a mutant SARS-CoV-2 that lacks the furin cleavage site (ΔPRRA) was generated, which had faster kinetics, improved fitness in Vero E6 cells and reduced spike protein processing.
A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2.
Ahmed O. Hassan,Natasha M. Kafai,Igor P. Dmitriev,Julie M. Fox,Brittany K. Smith,Ian B. Harvey,Rita E. Chen,Emma S. Winkler,Alex W. Wessel,James Brett Case,Elena A. Kashentseva,Broc T. McCune,Adam L. Bailey,Haiyan Zhao,Laura A. VanBlargan,Ya Nan Dai,Meisheng Ma,Lucas J. Adams,Swathi Shrihari,Jonathan E. Danis,Lisa E. Gralinski,Yixuan J. Hou,Alexandra Schäfer,Arthur S. Kim,Shamus P. Keeler,Daniela Weiskopf,Ralph S. Baric,Michael J. Holtzman,Daved H. Fremont,David T. Curiel,Michael S. Diamond +30 more
TL;DR: Intranasal administration of a chimpanzee adenovirus-vectored vaccine encoding a pre-fusion stabilized spike protein is a candidate for preventing SARS-CoV-2 infection and transmission, and curtailing pandemic spread.
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