Edward Monosov
Sanford-Burnham Institute for Medical Research
15 Papers
278 Citations
Edward Monosov is an academic researcher from Sanford-Burnham Institute for Medical Research. The author has contributed to research in topics: Biology & Apoptosis. The author has an hindex of 14, co-authored 15 publications. Previous affiliations of Edward Monosov include Discovery Institute.
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Papers
NG2 proteoglycan is expressed exclusively by mural cells during vascular morphogenesis
TL;DR: NG2 is expressed in the embryonic heart by cardiomyocytes, in developing macrovasculature by smooth muscle cells, and in nascent microvessels by vascular pericytes, and is especially useful for identification of this cell type due to the scarcity of proven markers.
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The Fas–FADD death domain complex structure unravels signalling by receptor clustering
Fiona L. Scott,Boguslaw Stec,Cristina Pop,Małgorzata K. Dobaczewska,JeongEun J. Lee,Edward Monosov,Howard Robinson,Guy S. Salvesen,Robert Schwarzenbacher,Stefan J. Riedl +9 more
TL;DR: The result is a regulatory Fas–FADD complex bridge governed by weak protein–protein interactions revealing a model where the complex itself functions as a mechanistic switch that prevents accidental DISC assembly, yet allows for highly processive DISC formation and clustering upon a sufficient stimulus.
MT1-MMP initiates activation of pro-MMP-2 and integrin alphavbeta3 promotes maturation of MMP-2 in breast carcinoma cells.
Elena I. Deryugina,Boris I. Ratnikov,Edward Monosov,Tanya I. Postnova,Richard G. DiScipio,Jeffrey W. Smith,Alex Y. Strongin +6 more
TL;DR: Cellular mechanisms involved in the activation pathway of matrix prometalloproteinase-2, an enzyme implicated in the malignant progression of many tumor types, appear to be instrumental to clustering active MMP-2 directly at the invadopodia and invasive front of alphavbeta3-expressing cells or in their close vicinity, thereby accelerating tumor cell locomotion.
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Mutation Analysis of Membrane Type-1 Matrix Metalloproteinase (MT1-MMP) THE ROLE OF THE CYTOPLASMIC TAIL CYS574, THE ACTIVE SITE GLU240, AND FURIN CLEAVAGE MOTIFS IN OLIGOMERIZATION, PROCESSING, AND SELF-PROTEOLYSIS OF MT1-MMP EXPRESSED IN BREAST CARCINOMA CELLS
Dmitry V. Rozanov,Elena I. Deryugina,Boris I. Ratnikov,Edward Monosov,George N. Marchenko,James P. Quigley,Alex Y. Strongin +6 more
TL;DR: The results supported the existence of MT1-MMP oligomers and demonstrated that a disulfide bridge involving the Cys574 of the enzyme's cytoplasmic tail covalently links MT1 -MMP monomers on the MCF7 cell surface.
173
Rational Design and Real Time, In-Cell Detection of the Proapoptotic Activity of a Novel Compound Targeting Bcl-XL
Barbara Becattini,Shinichi Kitada,Marilisa Leone,Edward Monosov,Sharon Chandler,Dayong Zhai,Thomas J. Kipps,John C. Reed,Maurizio Pellecchia +8 more
TL;DR: Preliminary data on cells freshly isolated from patients affected by chronic lymphocytic leukemia strongly suggest potential applications of Bcl-2 antagonists as chemosensitizers in cancer therapy.
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