Edward A. McKenzie
University of Manchester
36 Papers
147 Citations
Edward A. McKenzie is an academic researcher from University of Manchester. The author has contributed to research in topics: Heparanase & Urofacial syndrome. The author has an hindex of 20, co-authored 36 publications.
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Papers
Anti-PLA2R antibodies measured by ELISA predict long-term outcome in a prevalent population of patients with idiopathic membranous nephropathy
Durga Kanigicherla,Jennet Gummadova,Edward A. McKenzie,Stephen A Roberts,Shelley Harris,Milind Nikam,Kay Poulton,Lorna McWilliam,Colin D. Short,Michael Venning,Paul Brenchley +10 more
TL;DR: High levels of PLA2R antibodies are linked with active disease and a higher risk of declining renal function during follow-up, and future therapeutic trials in IMN should monitor anti-PLA2R, as patients with a high antibody burden may benefit from earlier therapeutic intervention.
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Identification of a Major Epitope Recognized by PLA2R Autoantibodies in Primary Membranous Nephropathy
Maryline Fresquet,Thomas A. Jowitt,Jennet Gummadova,Richard F. Collins,Ronan O’Cualain,Edward A. McKenzie,Rachel Lennon,Rachel Lennon,Paul Brenchley,Paul Brenchley +9 more
TL;DR: The location of a major epitope in the N-terminal cysteine-rich ricin domain of PLA2R that is recognized by 90% of human anti-PLA2R autoantibodies is described, which will enable further therapeutic advances for patients with idiopathic membranous nephropathy, including antibody inhibition therapy and immunoadsorption of circulating autoantsibodies.
Furanyl-1,3-thiazol-2-yl and benzoxazol-5-yl acetic acid derivatives : novel classes of heparanase inhibitor
Stephen Martin Courtney,Philip Andrew Hay,Richard T. Buck,Claire S. Colville,David Jonathan Phillips,David I. C. Scopes,Faye C. Pollard,Martin John Page,James M. Bennett,Margaret L. Hircock,Edward A. McKenzie,Maina Bhaman,Robert Felix,Colin Stubberfield,Turner Paul +14 more
TL;DR: Improvement to the DMPK profile of compounds has provided compounds of potential use in in vivo models and several of the compounds show anti-angiogenic properties.
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GAS2-like proteins mediate communication between microtubules and actin through interactions with end-binding proteins
Matthew J. Stroud,Alicja Nazgiewicz,Edward A. McKenzie,Yisu Wang,Richard A. Kammerer,Christoph Ballestrem +5 more
TL;DR: This work demonstrates that three members of the growth-arrest-specific 2 (GAS2) family are differentially involved in mediating the crosstalk between filamentous actin and microtubule (MT) and actin cytoskeletons, and leads to a model in which end-binding (EB) proteins play a key role in mediates actin–MT crosStalk.
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Alternative fusion protein strategies to express recalcitrant QconCAT proteins for quantitative proteomics of human drug metabolizing enzymes and transporters.
Matthew R. Russell,Brahim Achour,Edward A. McKenzie,Ruth Lopez,Matthew D Harwood,Amin Rostami-Hodjegan,Jill Barber +6 more
TL;DR: Two complementary methods are presented to express recalcitrant QconCAT proteins intended to quantify human hepatic enzymes and transporters.
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