Edsel Arce
Baylor University
5 Papers
Edsel Arce is an academic researcher from Baylor University. The author has contributed to research in topics: Lupus erythematosus & Autoimmunity. The author has an hindex of 5, co-authored 5 publications. Previous affiliations of Edsel Arce include University of Texas Southwestern Medical Center & Baylor University Medical Center.
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Papers
Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus Blood
Lynda Bennett,A. Karolina Palucka,Edsel Arce,Edsel Arce,Victoria Cantrell,Victoria Cantrell,Josef Borvak,Jacques Banchereau,Virginia Pascual,Virginia Pascual +9 more
TL;DR: Microarray analysis of blood cells reveals that immature granulocytes may be involved in SLE pathogenesis, and the IFN signature confirms the central role of this cytokine in Sle, using oligonucleotide microarrays.
Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade
Virginia Pascual,Virginia Pascual,Florence Allantaz,Edsel Arce,Marilynn Punaro,Marilynn Punaro,Jacques Banchereau +6 more
TL;DR: It is shown that serum from SoJIA patients induces the transcription of innate immunity genes, including interleukin (IL)-1 in healthy peripheral blood mononuclear cells (PBMCs), and that this cytokine represents a target for therapy in this disease.
Blood dendritic cells and DC-poietins in systemic lupus erythematosus
Michelle A. Gill,Patrick Blanco,Edsel Arce,Edsel Arce,Virginia Pascual,Virginia Pascual,Jacques Banchereau,A. Karolina Palucka +7 more
TL;DR: Results demonstrate profound alterations of DCs and DC-poietins homeostasis in SLE, and increased FMS-like tyrosine kinase 3-ligand and its correlation with soluble TNF receptors suggest a physiologic response to compensate low DC numbers.
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Update on pediatric systemic lupus erythematosus.
TL;DR: An important role for interferon-alpha (IFN-α) in the pathogenesis of this disease and an overall striking homogeneity of leukocyte gene expression profiles in children and adults with SLE are indicated.
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Increased Frequency of Pre-germinal Center B Cells and Plasma Cell Precursors in the Blood of Children with Systemic Lupus Erythematosus
Edsel Arce,Deborah G. Jackson,Michelle A. Gill,Michelle A. Gill,Lynda B. Bennett,Jacques Banchereau,Virginia Pascual +6 more
TL;DR: Pregerminal center cells in SLE are decreased to a lesser extent than conventional B cells, and therefore represent the predominant blood B cell subset in a number of patients, and SLE is associated with major blood B Cell subset alterations.