E. P. Greenberg
University of Washington
125 Papers
3.3K Citations
E. P. Greenberg is an academic researcher from University of Washington. The author has contributed to research in topics: Quorum sensing & Pseudomonas aeruginosa. The author has an hindex of 70, co-authored 122 publications. Previous affiliations of E. P. Greenberg include New Mexico State University & University of California, San Diego.
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Papers
Bacterial biofilms : A common cause of persistent infections
TL;DR: Improvements in understanding of the genetic and molecular basis of bacterial community behavior point to therapeutic targets that may provide a means for the control of biofilm infections.
The involvement of cell-to-cell signals in the development of a bacterial biofilm
David G. Davies,Matthew R. Parsek,Matthew R. Parsek,Matthew R. Parsek,James P. Pearson,James P. Pearson,James P. Pearson,Barbara H. Iglewski,Barbara H. Iglewski,Barbara H. Iglewski,J. W. Costerton,J. W. Costerton,J. W. Costerton,E. P. Greenberg,E. P. Greenberg,E. P. Greenberg +15 more
TL;DR: The involvement of an intercellular signal molecule in the development of Pseudomonas aeruginosa biofilms suggests possible targets to control biofilm growth on catheters, in cystic fibrosis, and in other environments where P. aerug inosaBiofilms are a persistent problem.
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Quorum sensing in bacteria: the LuxR-LuxI family of cell density-responsive transcriptional regulators.
TL;DR: How the marine luminescent bacterium V. fischeri uses the LuxR and LuxI proteins for intercellular communication is reviewed and a newly discovered family of LuxRand LuxI homologs in diverse bacterial species is described.
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Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms
Pradeep K. Singh,Amy L. Schaefer,Matthew R. Parsek,Thomas O. Moninger,Michael J. Welsh,E. P. Greenberg +5 more
TL;DR: The hypothesis that P. aeruginosa might exist as biofilms—structured communities of bacteria encased in a self-produced polymeric matrix—in the cystic fibrosis lung is supported by microscopy of cystic Fibrosis sputum, which shows that the bacterium are in biofilm-like structures.
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Census and consensus in bacterial ecosystems: the LuxR-LuxI family of quorum-sensing transcriptional regulators.
TL;DR: Genetic analyses of particular bacterial genes, operons, or regulons that are expressed preferentially at high cell densities have revealed a high degree of functional conservation, while also uncovering features that are unique to each.
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