Dennis van 't Ent
VU University Amsterdam
64 Papers
209 Citations
Dennis van 't Ent is an academic researcher from VU University Amsterdam. The author has contributed to research in topics: Biology & Genome-wide association study. The author has an hindex of 22, co-authored 54 publications. Previous affiliations of Dennis van 't Ent include VU University Medical Center & University of Amsterdam.
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Papers
The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data
Paul M. Thompson,Jason L. Stein,Sarah E. Medland,Derrek P. Hibar,Alejandro Arias Vasquez,Miguel E. Rentería,Roberto Toro,Neda Jahanshad,Gunter Schumann,Barbara Franke,Margaret J. Wright,Nicholas G. Martin,Ingrid Agartz,Ingrid Agartz,Martin Alda,Saud Alhusaini,Saud Alhusaini,Laura Almasy,Jorge R. C. Almeida,Jorge R. C. Almeida,Jorge R. C. Almeida,Kathryn I. Alpert,Nancy C. Andreasen,Ole A. Andreassen,Liana G. Apostolova,Katja Appel,Nicola J. Armstrong,Benjamin S. Aribisala,Mark E. Bastin,Michael Bauer,Carrie E. Bearden,Ørjan Bergmann,Elisabeth B. Binder,John Blangero,HJ Bockholt,Erlend Bøen,Catherine Bois,Dorret I. Boomsma,Tom Booth,Ian Bowman,Janita Bralten,Rachel M. Brouwer,Han G. Brunner,David G. Brohawn,Randy L. Buckner,Jan K. Buitelaar,Kazima B. Bulayeva,Juan R. Bustillo,Vince D. Calhoun,Vince D. Calhoun,Dara M. Cannon,Rita M. Cantor,Melanie A. Carless,Xavier Caseras,Gianpiero L. Cavalleri,M. Mallar Chakravarty,Kiki D. Chang,Christopher R.K. Ching,Andrea Christoforou,Andrea Christoforou,Sven Cichon,Sven Cichon,Vincent P. Clark,Patricia J. Conrod,Patricia J. Conrod,Giovanni Coppola,Benedicto Crespo-Facorro,Joanne E. Curran,Michael Czisch,Ian J. Deary,Eco J. C. de Geus,Anouk den Braber,G. Delvecchio,Chantal Depondt,Lieuwe de Haan,Lieuwe de Haan,Greig I. de Zubicaray,Danai Dima,Rali Dimitrova,Srdjan Djurovic,Hong-Wei Dong,Gary Donohoe,Gary Donohoe,Ravindranath Duggirala,Thomas D. Dyer,Stefan Ehrlich,Stefan Ehrlich,Carl Johan Ekman,Torbjørn Elvsåshagen,Louise Emsell,Susanne Erk,Thomas Espeseth,Jesen Fagerness,Scott C. Fears,Iryna O. Fedko,Guillén Fernández,Simon E. Fisher,Simon E. Fisher,Tatiana Foroud,Peter T. Fox,Clyde Francks,Clyde Francks,Sophia Frangou,Eva Maria Frey,Thomas Frodl,Thomas Frodl,Vincent Frouin,Hugh Garavan,Sudheer Giddaluru,David C. Glahn,Beata R. Godlewska,Rita Z. Goldstein,Randy L. Gollub,Hans J. Grabe,Oliver Grimm,Oliver Gruber,Tulio Guadalupe,Raquel E. Gur,Ruben C. Gur,Ruben C. Gur,Harald H H Göring,Saskia P. Hagenaars,Tomas Hajek,Geoffrey B. Hall,Jeremy Hall,Jeremy Hall,John Hardy,Catharina A. Hartman,Johanna Hass,Sean N. Hatton,Unn K. Haukvik,K Hegenscheid,Andreas Heinz,Ian B. Hickie,Beng-Choon Ho,D. Hoehn,Pieter J. Hoekstra,Marisa O. Hollinshead,Avram J. Holmes,Georg Homuth,Martine Hoogman,L. Elliot Hong,Norbert Hosten,Jouke-Jan Hottenga,Hilleke E. Hulshoff Pol,Kristy S. Hwang,Clifford R. Jack,Mark Jenkinson,Caroline Johnston,Caroline Johnston,Erik G. Jönsson,René S. Kahn,Dalia Kasperaviciute,Sinead Kelly,Sungeun Kim,Peter Kochunov,Laura Koenders,Laura Koenders,Bernd Krämer,John B.J. Kwok,John B.J. Kwok,Jim Lagopoulos,Gonzalo Laje,Mikael Landén,Mikael Landén,Bennett A. Landman,John Lauriello,Stephen M. Lawrie,Phil Lee,Phil Lee,Stephanie Le Hellard,Stephanie Le Hellard,Herve Lemaitre,Cassandra D. Leonardo,Chiang shan Li,Benny Liberg,David C. Liewald,Xinmin Liu,Xinmin Liu,Lorna M. Lopez,Eva Loth,Anbarasu Lourdusamy,Michelle Luciano,Fabio Macciardi,Fabio Macciardi,Marise W. J. Machielsen,Marise W. J. Machielsen,Glenda MacQueen,Ulrik Fredrik Malt,René C.W. Mandl,Dara S. Manoach,Jean-Luc Martinot,Mar Matarin,Karen A. Mather,Manuel Mattheisen,Manuel Mattheisen,Morten Mattingsdal,Andreas Meyer-Lindenberg,Colm McDonald,Andrew M. McIntosh,Francis J. McMahon,Katie L. McMahon,Eva M. Meisenzahl,Ingrid Melle,Yuri Milaneschi,Yuri Milaneschi,Sebastian Mohnke,Grant W. Montgomery,Derek W. Morris,Eric K. Moses,Eric K. Moses,Bryon A. Mueller,Susana Muñoz Maniega,Thomas W. Mühleisen,Bertram Müller-Myhsok,Benson Mwangi,Matthias Nauck,Kwangsik Nho,Thomas E. Nichols,Lars-Göran Nilsson,Lars-Göran Nilsson,Allison C. Nugent,Lars Nyberg,Rene L. Olvera,Jaap Oosterlaan,Roel A. Ophoff,Roel A. Ophoff,Massimo Pandolfo,Melina Papalampropoulou-Tsiridou,Martina Papmeyer,Tomáš Paus,Zdenka Pausova,Godfrey D. Pearlson,Godfrey D. Pearlson,Brenda W.J.H. Penninx,Charles P. Peterson,Andrea Pfennig,Mary L. Phillips,G. Bruce Pike,Jean-Baptiste Poline,Steven G. Potkin,Benno Pütz,Adaikalavan Ramasamy,Adaikalavan Ramasamy,Jerod M. Rasmussen,Marcella Rietschel,Mark Rijpkema,Shannon L. Risacher,Joshua L. Roffman,Roberto Roiz-Santiañez,Nina Romanczuk-Seiferth,Emma J. Rose,Natalie A. Royle,Dan Rujescu,Mina Ryten,Mina Ryten,Perminder S. Sachdev,Alireza Salami,Alireza Salami,Theodore D. Satterthwaite,Jonathan Savitz,Jonathan Savitz,Andrew J. Saykin,Cathy Scanlon,Lianne Schmaal,Hugo G. Schnack,Andrew J. Schork,S. Charles Schulz,Remmelt R. Schür,Larry J. Seidman,Li Shen,Jody M. Shoemaker,Andrew Simmons,Andrew Simmons,Sanjay M. Sisodiya,Colin Smith,Jordan W. Smoller,Jordan W. Smoller,Jair C. Soares,Scott R. Sponheim,Scott R. Sponheim,Emma Sprooten,John M. Starr,Vidar M. Steen,Vidar M. Steen,Stephen M. Strakowski,Lachlan T. Strike,Jessika E. Sussmann,Philipp G. Sämann,Alexander Teumer,Arthur W. Toga,Diana Tordesillas-Gutiérrez,Daniah Trabzuni,Daniah Trabzuni,Sarah Trost,Jessica A. Turner,Jessica A. Turner,Martijn P. van den Heuvel,Nic J.A. van der Wee,Kristel R. van Eijk,Theo G.M. van Erp,Neeltje E.M. van Haren,Dennis van 't Ent,Marie-José van Tol,Maria C. Valdés Hernández,Dick J. Veltman,Amelia Versace,Henry Völzke,Robert Walker,Henrik Walter,Henrik Walter,Lei Wang,Joanna M. Wardlaw,Michael E. Weale,Michael W. Weiner,Wei Wen,Lars T. Westlye,Heather C. Whalley,Christopher D. Whelan,Tonya White,Anderson M. Winkler,Anderson M. Winkler,Katharina Wittfeld,Girma Woldehawariat,Christiane Wolf,David Zilles,Marcel P. Zwiers,Anbupalam Thalamuthu,Peter R. Schofield,Peter R. Schofield,Nelson B. Freimer,Natalia Lawrence,Wayne C. Drevets +332 more
TL;DR: The ENIGMA Consortium has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected.
Common genetic variants influence human subcortical brain structures.
Derrek P. Hibar,Jason L. Stein,Jason L. Stein,Miguel E. Rentería,Alejandro Arias-Vasquez,Sylvane Desrivières,Neda Jahanshad,Roberto Toro,Roberto Toro,Katharina Wittfeld,Katharina Wittfeld,Lucija Abramovic,Micael Andersson,Benjamin S. Aribisala,Benjamin S. Aribisala,Nicola J. Armstrong,Nicola J. Armstrong,Manon Bernard,Marc M. Bohlken,Marco P. Boks,Janita Bralten,Andrew A. Brown,M. Mallar Chakravarty,M. Mallar Chakravarty,Qiang Chen,Christopher R.K. Ching,Christopher R.K. Ching,Gabriel Cuellar-Partida,Anouk den Braber,Sudheer Giddaluru,Aaron Goldman,Oliver Grimm,Tulio Guadalupe,Johanna Hass,Girma Woldehawariat,Avram J. Holmes,Avram J. Holmes,Martine Hoogman,Deborah Janowitz,Tianye Jia,Sungeun Kim,Marieke Klein,Bernd Kraemer,Phil Lee,Phil Lee,Loes M. Olde Loohuis,Michelle Luciano,Christine Macare,Karen A. Mather,Manuel Mattheisen,Manuel Mattheisen,Yuri Milaneschi,Kwangsik Nho,Martina Papmeyer,Adaikalavan Ramasamy,Adaikalavan Ramasamy,Shannon L. Risacher,Roberto Roiz-Santiañez,Emma J. Rose,Alireza Salami,Alireza Salami,Philipp G. Sämann,Lianne Schmaal,Andrew J. Schork,Jean Shin,Lachlan T. Strike,Lachlan T. Strike,Alexander Teumer,Marjolein M.J. van Donkelaar,Kristel R. van Eijk,Raymond K. Walters,Raymond K. Walters,Lars T. Westlye,Christopher D. Whelan,Anderson M. Winkler,Anderson M. Winkler,Marcel P. Zwiers,Saud Alhusaini,Saud Alhusaini,Lavinia Athanasiu,Stefan Ehrlich,Stefan Ehrlich,Marina Hakobjan,Cecilie B. Hartberg,Unn K. Haukvik,Angelien Heister,D. Hoehn,Dalia Kasperaviciute,Dalia Kasperaviciute,David C. Liewald,Lorna M. Lopez,Remco R. R. Makkinje,Mar Matarin,Marlies Naber,D. Reese McKay,Margaret Needham,Allison C. Nugent,Benno Pütz,Natalie A. Royle,Li Shen,Emma Sprooten,Emma Sprooten,Daniah Trabzuni,Daniah Trabzuni,Saskia S. L. van der Marel,Kimm J. E. van Hulzen,Esther Walton,Christiane Wolf,Laura Almasy,Laura Almasy,David Ames,David Ames,Sampath Arepalli,Amelia A. Assareh,Mark E. Bastin,Henry Brodaty,Kazima B. Bulayeva,Melanie A. Carless,Sven Cichon,Sven Cichon,Aiden Corvin,Joanne E. Curran,Michael Czisch,Greig I. de Zubicaray,Allissa Dillman,Ravi Duggirala,Thomas D. Dyer,Thomas D. Dyer,Susanne Erk,Iryna O. Fedko,Luigi Ferrucci,Tatiana Foroud,Peter T. Fox,Peter T. Fox,Masaki Fukunaga,J. Raphael Gibbs,J. Raphael Gibbs,Harald H H Göring,Robert C. Green,Sebastian Guelfi,Narelle K. Hansell,Catharina A. Hartman,Katrin Hegenscheid,Andreas Heinz,Dena G. Hernandez,Dena G. Hernandez,Dirk J. Heslenfeld,Pieter J. Hoekstra,Florian Holsboer,Georg Homuth,Jouke-Jan Hottenga,Masashi Ikeda,Clifford R. Jack,Mark Jenkinson,Robert Johnson,Ryota Kanai,Ryota Kanai,Maria Keil,Jack W. Kent,Peter Kochunov,John B.J. Kwok,John B.J. Kwok,Stephen M. Lawrie,Xinmin Liu,Xinmin Liu,Dan L. Longo,Katie L. McMahon,Eva M. Meisenzahl,Ingrid Melle,Sebastian Mohnke,Grant W. Montgomery,Jeanette C. Mostert,Thomas W. Mühleisen,Mike A. Nalls,Thomas E. Nichols,Thomas E. Nichols,Lars Nilsson,Markus M. Nöthen,Kazutaka Ohi,Rene L. Olvera,Rocío Pérez-Iglesias,G. Bruce Pike,Steven G. Potkin,Ivar Reinvang,Simone Reppermund,Marcella Rietschel,Nina Romanczuk-Seiferth,Glenn D. Rosen,Dan Rujescu,Knut Schnell,Peter R. Schofield,Peter R. Schofield,Colin Smith,Vidar M. Steen,Jessika E. Sussmann,Anbupalam Thalamuthu,Arthur W. Toga,Bryan J. Traynor,Juan C. Troncoso,Jessica A. Turner,Maria C. Valdés Hernández,Dennis van 't Ent,Marcel P. van der Brug,Nic J.A. van der Wee,Marie-José van Tol,Dick J. Veltman,Thomas H. Wassink,Eric Westman,Ronald H. Zielke,Alan B. Zonderman,David G. Ashbrook,Reinmar Hager,Lu Lu,Lu Lu,Francis J. McMahon,Derek W. Morris,Derek W. Morris,Robert W. Williams,Han G. Brunner,Han G. Brunner,Randy L. Buckner,Jan K. Buitelaar,Wiepke Cahn,Vince D. Calhoun,Vince D. Calhoun,Gianpiero L. Cavalleri,Benedicto Crespo-Facorro,Anders M. Dale,Gareth E. Davies,Norman Delanty,Norman Delanty,Chantal Depondt,Srdjan Djurovic,Wayne C. Drevets,Wayne C. Drevets,Thomas Espeseth,Randy L. Gollub,Beng-Choon Ho,Wolfgang Hoffmann,Wolfgang Hoffmann,Norbert Hosten,René S. Kahn,Stephanie Le Hellard,Andreas Meyer-Lindenberg,Bertram Müller-Myhsok,Bertram Müller-Myhsok,Matthias Nauck,Lars Nyberg,Massimo Pandolfo,Brenda W.J.H. Penninx,Joshua L. Roffman,Sanjay M. Sisodiya,Jordan W. Smoller,Jordan W. Smoller,Hans van Bokhoven,Neeltje E.M. van Haren,Henry Völzke,Henrik Walter,Michael W. Weiner,Wei Wen,Tonya White,Ingrid Agartz,Ingrid Agartz,Ole A. Andreassen,John Blangero,John Blangero,Dorret I. Boomsma,Rachel M. Brouwer,Dara M. Cannon,Dara M. Cannon,Mark R. Cookson,Eco J. C. de Geus,Ian J. Deary,Gary Donohoe,Gary Donohoe,Guillén Fernández,Simon E. Fisher,Simon E. Fisher,Clyde Francks,Clyde Francks,David C. Glahn,Hans J. Grabe,Oliver Gruber,Oliver Gruber,John Hardy,Ryota Hashimoto,Hilleke E. Hulshoff Pol,Erik G. Jönsson,Erik G. Jönsson,Iwona Kłoszewska,Simon Lovestone,Simon Lovestone,Venkata S. Mattay,Patrizia Mecocci,Colm McDonald,Andrew M. McIntosh,Roel A. Ophoff,Roel A. Ophoff,Tomáš Paus,Zdenka Pausova,Mina Ryten,Mina Ryten,Perminder S. Sachdev,Andrew J. Saykin,Andrew J. Saykin,Andrew Simmons,Andrew B. Singleton,Hilkka Soininen,Joanna M. Wardlaw,Michael E. Weale,Daniel R. Weinberger,Hieab H.H. Adams,Lenore J. Launer,Stephan Seiler,Reinhold Schmidt,Ganesh Chauhan,Claudia L. Satizabal,Claudia L. Satizabal,James T. Becker,Lisa R. Yanek,Sven J. van der Lee,Maritza Ebling,Bruce Fischl,Bruce Fischl,W. T. Longstreth,Douglas N. Greve,Helena Schmidt,Paul A. Nyquist,Louis N. Vinke,Cornelia M. van Duijn,Luting Xue,Bernard Mazoyer,Joshua C. Bis,Vilmundur Gudnason,Sudha Seshadri,Sudha Seshadri,M. Arfan Ikram,Nicholas G. Martin,Margaret J. Wright,Margaret J. Wright,Gunter Schumann,Barbara Franke,Barbara Franke,Paul M. Thompson,Sarah E. Medland +344 more
TL;DR: In this paper, the authors conduct genome-wide association studies of the volumes of seven subcortical regions and the intracranial volume derived from magnetic resonance images of 30,717 individuals from 50 cohorts.
The genetic architecture of the human cerebral cortex
Katrina L. Grasby,Neda Jahanshad,Jodie N. Painter,Lucía Colodro-Conde,Janita Bralten,Derrek P. Hibar,Penelope A. Lind,Fabrizio Pizzagalli,Christopher R.K. Ching,Mary Agnes McMahon,Natalia Shatokhina,Leo Charles Peek Zsembik,Sophia I. Thomopoulos,Alyssa H. Zhu,Lachlan T. Strike,Ingrid Agartz,Saud Alhusaini,Marcio Almeida,Dag Alnæs,Inge K Amlien,Micael Andersson,Tyler Ard,Nicola J. Armstrong,Allison E. Ashley-Koch,Joshua R. Atkins,Manon Bernard,Rachel M. Brouwer,Elizabeth E.L. Buimer,Robin Bülow,Christian Bürger,Dara M. Cannon,M. Mallar Chakravarty,Qiang Chen,Joshua W. Cheung,Baptiste Couvy-Duchesne,Anders M. Dale,Shareefa Dalvie,Tânia Kawasaki de Araujo,Greig I. de Zubicaray,Sonja M C de Zwarte,Anouk den Braber,Nhat Trung Doan,Katharina Dohm,Stefan Ehrlich,Hannah-Ruth Engelbrecht,Susanne Erk,Chun Chieh Fan,Iryna O. Fedko,Sonya Foley,Judith M. Ford,Masaki Fukunaga,Melanie E. Garrett,Tian Ge,Sudheer Giddaluru,Aaron L. Goldman,Melissa J. Green,Nynke A. Groenewold,Dominik Grotegerd,Tiril P. Gurholt,Boris A. Gutman,Narelle K. Hansell,Mathew A. Harris,Marc B. Harrison,Courtney C. Haswell,Michael A. Hauser,Stefan Herms,Dirk J. Heslenfeld,New Fei Ho,D. Hoehn,Per Hoffmann,Laurena Holleran,Martine Hoogman,Jouke-Jan Hottenga,Masashi Ikeda,Deborah Janowitz,Iris E. Jansen,Tianye Jia,Christiane Jockwitz,Ryota Kanai,Sherif Karama,Dalia Kasperaviciute,Tobias Kaufmann,Sinead Kelly,Masataka Kikuchi,Marieke Klein,Michael Knapp,Annchen R. Knodt,Bernd Kramer,Max Lam,Thomas M. Lancaster,Phil Lee,Tristram A. Lett,Lindsay B. Lewis,Iscia Lopes-Cendes,Michelle Luciano,Fabio Macciardi,Andre F. Marquand,Samuel R. Mathias,Tracy R. Melzer,Yuri Milaneschi,Nazanin Mirza-Schreiber,José C. V. Moreira,Thomas W. Mühleisen,Bertram Müller-Myhsok,Pablo Najt,Soichiro Nakahara,Kwangsik Nho,Loes M. Olde Loohuis,Dimitri Papadopoulos Orfanos,John F. Pearson,Toni L. Pitcher,Benno Pütz,Yann Quidé,Anjanibhargavi Ragothaman,Faisal Rashid,William R. Reay,Ronny Redlich,Céline S. Reinbold,Jonathan Repple,Geneviève Richard,Brandalyn C. Riedel,Shannon L. Risacher,Cristiane S. Rocha,Nina Roth Mota,Lauren E. Salminen,Arvin Saremi,Andrew J. Saykin,Fenja Schlag,Lianne Schmaal,Peter R. Schofield,Rodrigo Secolin,Chin Yang Shapland,Li Shen,Jean Shin,Elena Shumskaya,Ida E Sønderby,Emma Sprooten,Katherine E. Tansey,Alexander Teumer,Anbupalam Thalamuthu,Diana Tordesillas-Gutiérrez,Jessica A. Turner,Anne Uhlmann,Costanza L. Vallerga,Dennis van der Meer,Marjolein M. J. Van Donkelaar,Liza van Eijk,Theo G.M. van Erp,Neeltje E.M. van Haren,Daan van Rooij,Marie-José van Tol,Jan H. Veldink,Ellen Verhoef,Esther Walton,Mingyuan Wang,Yunpeng Wang,Joanna M. Wardlaw,Wei Wen,Lars T. Westlye,Christopher D. Whelan,Stephanie H. Witt,Katharina Wittfeld,Christiane Wolf,Thomas Wolfers,Jing Qin Wu,Clarissa L. Yasuda,Dario Zaremba,Zuo Zhang,Marcel P. Zwiers,Eric Artiges,Amelia A. Assareh,Rosa Ayesa-Arriola,Aysenil Belger,Christine L. Brandt,Gregory G. Brown,Sven Cichon,Joanne E. Curran,Gareth E. Davies,Franziska Degenhardt,Michelle F. Dennis,Bruno Dietsche,Srdjan Djurovic,Colin P. Doherty,Ryan Espiritu,Daniel Garijo,Yolanda Gil,Penny A. Gowland,Robert C. Green,Alexander N. Häusler,Walter Heindel,Beng-Choon Ho,Wolfgang Hoffmann,Florian Holsboer,Georg Homuth,Norbert Hosten,Clifford R. Jack,MiHyun Jang,Andreas Jansen,Nathan A. Kimbrel,Knut K. Kolskår,Sanne Koops,Axel Krug,Kelvin O. Lim,Jurjen J. Luykx,Daniel H. Mathalon,Karen A. Mather,Venkata S. Mattay,Sarah Matthews,Jaqueline Mayoral Van Son,Sarah McEwen,Ingrid Melle,Derek W. Morris,Bryon A. Mueller,Matthias Nauck,Jan Egil Nordvik,Markus M. Nöthen,Daniel S. O'Leary,Nils Opel,Marie-Laure Paillère Martinot,G. Bruce Pike,Adrian Preda,Erin Burke Quinlan,Paul E. Rasser,Varun Ratnakar,Simone Reppermund,Vidar M. Steen,Paul A. Tooney,Fábio R. Torres,Dick J. Veltman,James T. Voyvodic,Robert Whelan,Tonya White,Hidenaga Yamamori,Hieab H.H. Adams,Joshua C. Bis,Stéphanie Debette,Charles DeCarli,Myriam Fornage,Vilmundur Gudnason,Edith Hofer,M. Arfan Ikram,Lenore J. Launer,William T. Longstreth,Oscar L. Lopez,Bernard Mazoyer,Thomas H. Mosley,Gennady V. Roshchupkin,Claudia L. Satizabal,Reinhold Schmidt,Sudha Seshadri,Qiong Yang,Marina K. M. Alvim,David Ames,Tim J. Anderson,Ole A. Andreassen,Alejandro Arias-Vasquez,Mark E. Bastin,Bernhard T. Baune,Jean C. Beckham,John Blangero,Dorret I. Boomsma,Henry Brodaty,Han G. Brunner,Randy L. Buckner,Jan K. Buitelaar,Juan R. Bustillo,Wiepke Cahn,Murray J. Cairns,Vince D. Calhoun,Vaughan J. Carr,Xavier Caseras,Svenja Caspers,Gianpiero L. Cavalleri,Fernando Cendes,Aiden Corvin,Benedicto Crespo-Facorro,John C. Dalrymple-Alford,Udo Dannlowski,Eco J. C. de Geus,Ian J. Deary,Norman Delanty,Chantal Depondt,Sylvane Desrivières,Gary Donohoe,Thomas Espeseth,Guillén Fernández,Simon E. Fisher,Herta Flor,Andreas J. Forstner,Clyde Francks,Barbara Franke,David C. Glahn,Randy L. Gollub,Hans J. Grabe,Oliver Gruber,Asta Håberg,Ahmad R. Hariri,Catharina A. Hartman,Ryota Hashimoto,Andreas Heinz,Frans Henskens,Manon H.J. Hillegers,Pieter J. Hoekstra,Avram J. Holmes,L. Elliot Hong,William D. Hopkins,Hilleke E. Hulshoff Pol,Terry L. Jernigan,Erik G. Jönsson,René S. Kahn,Martin A. Kennedy,Tilo Kircher,Peter Kochunov,John B.J. Kwok,Stephanie Le Hellard,Carmel M. Loughland,Nicholas G. Martin,Jean-Luc Martinot,Colm McDonald,Katie L. McMahon,Andreas Meyer-Lindenberg,Patricia T. Michie,Rajendra A. Morey,Bryan J. Mowry,Lars Nyberg,Jaap Oosterlaan,Roel A. Ophoff,Christos Pantelis,Tomáš Paus,Zdenka Pausova,Brenda W.J.H. Penninx,Tinca J. C. Polderman,Danielle Posthuma,Marcella Rietschel,Joshua L. Roffman,Laura M. Rowland,Perminder S. Sachdev,Philipp G. Sämann,Ulrich Schall,Gunter Schumann,Rodney J. Scott,Kang Sim,Sanjay M. Sisodiya,Jordan W. Smoller,Iris E. C. Sommer,Beate St Pourcain,Dan J. Stein,Arthur W. Toga,Julian N. Trollor,Nic J.A. van der Wee,Dennis van 't Ent,Henry Völzke,Henrik Walter,Bernd Weber,Daniel R. Weinberger,Margaret J. Wright,Juan Zhou,Jason L. Stein,Paul M. Thompson,Sarah E. Medland +359 more
TL;DR: Results support the radial unit hypothesis that different developmental mechanisms promote surface area expansion and increases in thickness and find evidence that brain structure is a key phenotype along the causal pathway that leads from genetic variation to differences in general cognitive function.
Novel genetic loci associated with hippocampal volume
Derrek P. Hibar,Hieab H.H. Adams,Neda Jahanshad,Ganesh Chauhan,Jason L. Stein,Jason L. Stein,Edith Hofer,Miguel E. Rentería,Joshua C. Bis,Alejandro Arias-Vasquez,M. Kamran Ikram,Sylvane Desrivières,Meike W. Vernooij,Lucija Abramovic,Saud Alhusaini,Saud Alhusaini,Najaf Amin,Micael Andersson,Konstantinos Arfanakis,Konstantinos Arfanakis,Benjamin S. Aribisala,Benjamin S. Aribisala,Nicola J. Armstrong,Nicola J. Armstrong,Lavinia Athanasiu,Tomas Axelsson,Ashley Beecham,Alexa S. Beiser,Alexa S. Beiser,Manon Bernard,Susan H. Blanton,Marc M. Bohlken,Marco P. Boks,Janita Bralten,Adam M. Brickman,Owen Carmichael,M. Mallar Chakravarty,M. Mallar Chakravarty,Qiang Chen,Christopher R.K. Ching,Christopher R.K. Ching,Vincent Chouraki,Vincent Chouraki,Vincent Chouraki,Gabriel Cuellar-Partida,Fabrice Crivello,Anouk den Braber,Nhat Trung Doan,Stefan Ehrlich,Stefan Ehrlich,Sudheer Giddaluru,Aaron Goldman,Rebecca F. Gottesman,Oliver Grimm,Michael Griswold,Tulio Guadalupe,Boris A. Gutman,Johanna Hass,Unn K. Haukvik,D. Hoehn,Avram J. Holmes,Avram J. Holmes,Martine Hoogman,Deborah Janowitz,Tianye Jia,Kjetil Nordbø Jørgensen,Nazanin Karbalai,Dalia Kasperaviciute,Dalia Kasperaviciute,Sungeun Kim,Marieke Klein,Bernd Kraemer,Phil Lee,Phil Lee,David C. Liewald,Lorna M. Lopez,Michelle Luciano,Christine Macare,Andre F. Marquand,Mar Matarin,Mar Matarin,Karen A. Mather,Manuel Mattheisen,Manuel Mattheisen,David R. McKay,Yuri Milaneschi,Susana Muñoz Maniega,Kwangsik Nho,Allison C. Nugent,Paul A. Nyquist,Loes M. Olde Loohuis,Jaap Oosterlaan,Martina Papmeyer,Martina Papmeyer,Lukas Pirpamer,Benno Pütz,Adaikalavan Ramasamy,Adaikalavan Ramasamy,Adaikalavan Ramasamy,Jennifer S. Richards,Shannon L. Risacher,Roberto Roiz-Santiañez,Nanda Rommelse,Stefan Ropele,Emma J. Rose,Natalie A. Royle,Tatjana Rundek,Philipp G. Sämann,Arvin Saremi,Claudia L. Satizabal,Claudia L. Satizabal,Lianne Schmaal,Lianne Schmaal,Andrew J. Schork,Li Shen,Jean Shin,Elena Shumskaya,Albert V. Smith,Emma Sprooten,Emma Sprooten,Lachlan T. Strike,Lachlan T. Strike,Alexander Teumer,Diana Tordesillas-Gutiérrez,Roberto Toro,Daniah Trabzuni,Daniah Trabzuni,Stella Trompet,Dhananjay Vaidya,Jeroen van der Grond,Sven J. van der Lee,Dennis van der Meer,Marjolein M.J. van Donkelaar,Kristel R. van Eijk,Theo G.M. van Erp,Daan van Rooij,Daan van Rooij,Esther Walton,Esther Walton,Lars T. Westlye,Lars T. Westlye,Christopher D. Whelan,Christopher D. Whelan,Beverly G. Windham,Anderson M. Winkler,Anderson M. Winkler,Katharina Wittfeld,Katharina Wittfeld,Girma Woldehawariat,Christiane Wolf,Thomas Wolfers,Lisa R. Yanek,Jingyun Yang,Jingyun Yang,Alex P. Zijdenbos,Marcel P. Zwiers,Ingrid Agartz,Ingrid Agartz,Laura Almasy,Laura Almasy,Laura Almasy,D. Ames,D. Ames,Philippe Amouyel,Ole A. Andreassen,Sampath Arepalli,Amelia A. Assareh,Sandra Barral,Mark E. Bastin,Diane M. Becker,James T. Becker,David A. Bennett,David A. Bennett,John Blangero,Hans van Bokhoven,Dorret I. Boomsma,Henry Brodaty,Henry Brodaty,Rachel M. Brouwer,Han G. Brunner,Han G. Brunner,Randy L. Buckner,Randy L. Buckner,Jan K. Buitelaar,Kazima B. Bulayeva,Wiepke Cahn,Vince D. Calhoun,Dara M. Cannon,Dara M. Cannon,Gianpiero L. Cavalleri,Ching-Yu Cheng,Ching-Yu Cheng,Ching-Yu Cheng,Sven Cichon,Sven Cichon,Sven Cichon,M. R. Cookson,Aiden Corvin,Benedicto Crespo-Facorro,Joanne E. Curran,Michael Czisch,Anders M. Dale,Gareth E. Davies,Anton J. M. de Craen,Eco J. C. de Geus,Philip L. De Jager,Philip L. De Jager,Philip L. De Jager,Greig I. de Zubicaray,Ian J. Deary,Stéphanie Debette,Stéphanie Debette,Stéphanie Debette,Charles C. DeCarli,Norman Delanty,Norman Delanty,Chantal Depondt,Anita L. DeStefano,Anita L. DeStefano,Allissa Dillman,Srdjan Djurovic,Srdjan Djurovic,G. Donohoe,G. Donohoe,Wayne C. Drevets,Wayne C. Drevets,Ravi Duggirala,Thomas D. Dyer,Christian Enzinger,Susanne Erk,Thomas Espeseth,Thomas Espeseth,Iryna O. Fedko,Guillén Fernández,Luigi Ferrucci,Simon E. Fisher,Simon E. Fisher,Debra A. Fleischman,Debra A. Fleischman,Ian Ford,Myriam Fornage,Tatiana Foroud,Tatiana Foroud,Peter T. Fox,Clyde Francks,Clyde Francks,Masaki Fukunaga,J. Raphael Gibbs,J. Raphael Gibbs,David C. Glahn,Randy L. Gollub,Harald H.H. Göring,Robert C. Green,Robert C. Green,Oliver Gruber,Vilmundur Gudnason,Sebastian Guelfi,Asta Håberg,Asta Håberg,Narelle K. Hansell,Narelle K. Hansell,John Hardy,Catharina A. Hartman,Ryota Hashimoto,Ryota Hashimoto,K Hegenscheid,Andreas Heinz,Stephanie Le Hellard,Dena G. Hernandez,Dena G. Hernandez,Dirk J. Heslenfeld,Beng-Choon Ho,Pieter J. Hoekstra,Wolfgang Hoffmann,Wolfgang Hoffmann,Albert Hofman,Florian Holsboer,Florian Holsboer,Georg Homuth,Norbert Hosten,Jouke-Jan Hottenga,Matthew J. Huentelman,Hilleke E. Hulshoff Pol,Masashi Ikeda,Clifford R. Jack,Mark Jenkinson,Robert Johnson,Erik G. Jönsson,Erik G. Jönsson,J. Wouter Jukema,René S. Kahn,Ryota Kanai,Ryota Kanai,Ryota Kanai,I. Kloszewska,David S. Knopman,Peter Kochunov,John B.J. Kwok,John B.J. Kwok,Stephen M. Lawrie,Herve Lemaitre,Xinmin Liu,Xinmin Liu,Dan L. Longo,Oscar L. Lopez,Simon Lovestone,Simon Lovestone,Oliver Martinez,Jean-Luc Martinot,Venkata S. Mattay,Venkata S. Mattay,C. McDonald,Andrew M. McIntosh,Francis J. McMahon,Katie L. McMahon,P. Mecocci,Ingrid Melle,Andreas Meyer-Lindenberg,Sebastian Mohnke,Grant W. Montgomery,D. Morris,Thomas H. Mosley,Thomas W. Mühleisen,Thomas W. Mühleisen,Bertram Müller-Myhsok,Bertram Müller-Myhsok,Michael A. Nalls,Matthias Nauck,Matthias Nauck,Thomas E. Nichols,Wiro J. Niessen,Wiro J. Niessen,Markus M. Nöthen,Markus M. Nöthen,Lars Nyberg,Kazutaka Ohi,Rene L. Olvera,Roel A. Ophoff,Roel A. Ophoff,Massimo Pandolfo,Tomáš Paus,Tomáš Paus,Zdenka Pausova,Zdenka Pausova,Brenda W.J.H. Penninx,G. Bruce Pike,G. Bruce Pike,Steven G. Potkin,Bruce M. Psaty,Simone Reppermund,Simone Reppermund,Marcella Rietschel,Joshua L. Roffman,Nina Romanczuk-Seiferth,Jerome I. Rotter,Mina Ryten,Mina Ryten,Ralph L. Sacco,Ralph L. Sacco,Perminder S. Sachdev,Perminder S. Sachdev,Andrew J. Saykin,Andrew J. Saykin,Reinhold Schmidt,Helena Schmidt,Peter R. Schofield,Peter R. Schofield,Sigurdur Sigursson,Andrew Simmons,Andrew Simmons,Andrew Singleton,Sanjay M. Sisodiya,Colin Smith,Jordan W. Smoller,Jordan W. Smoller,Hilkka Soininen,Hilkka Soininen,Vidar M. Steen,David J. Stott,Jessika E. Sussmann,Anbupalam Thalamuthu,Arthur W. Toga,Bryan J. Traynor,Juan C. Troncoso,Magda Tsolaki,Christophe Tzourio,Christophe Tzourio,Andre G. Uitterlinden,Andre G. Uitterlinden,Maria del C. Valdés Hernández,Marcel Van Der Brug,Aad van der Lugt,Nic J.A. van der Wee,Neeltje E.M. van Haren,Dennis van 't Ent,Marie-José van Tol,Badri N. Vardarajan,Bruno Vellas,Dick J. Veltman,Henry Völzke,Henrik Walter,Joanna M. Wardlaw,Thomas H. Wassink,Michael E. Weale,Daniel R. Weinberger,Michael Weiner,Wei Wen,Wei Wen,Eric Westman,Tonya White,Tonya White,Tien Yin Wong,Tien Yin Wong,Tien Yin Wong,Clinton B. Wright,Clinton B. Wright,Ronald H. Zielke,Alan B. Zonderman,Nicholas G. Martin,Cornelia M. van Duijn,Margaret J. Wright,Margaret J. Wright,William T. Longstreth,Gunter Schumann,Hans J. Grabe,Barbara Franke,Lenore J. Launer,Sarah E. Medland,Sudha Seshadri,Sudha Seshadri,Paul M. Thompson,M. Arfan Ikram,M. Arfan Ikram +432 more
TL;DR: It is shown that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg=−0.155), and these findings suggest novel biological pathways through which human genetic variation influences hippocampus volume and risk for neuropsychiatric illness.
Genetic architecture of subcortical brain structures in 38,851 individuals
Claudia L. Satizabal,Claudia L. Satizabal,Claudia L. Satizabal,Hieab H.H. Adams,Derrek P. Hibar,Charles C. White,Charles C. White,Maria J. Knol,Jason L. Stein,Jason L. Stein,Markus Scholz,Muralidharan Sargurupremraj,Neda Jahanshad,Gennady V. Roshchupkin,Albert V. Smith,Albert V. Smith,Joshua C. Bis,Xueqiu Jian,Michelle Luciano,Edith Hofer,Alexander Teumer,Sven J. van der Lee,Jingyun Yang,Lisa R. Yanek,Tom V. Lee,Shuo Li,Yanhui Hu,Jia Yu Koh,John D. Eicher,Sylvane Desrivières,Alejandro Arias-Vasquez,Ganesh Chauhan,Ganesh Chauhan,Lavinia Athanasiu,Lavinia Athanasiu,Miguel E. Rentería,Sungeun Kim,D. Hoehn,Nicola J. Armstrong,Qiang Chen,Avram J. Holmes,Avram J. Holmes,Anouk den Braber,Iwona Kłoszewska,Micael Andersson,Thomas Espeseth,Thomas Espeseth,Oliver Grimm,Lucija Abramovic,Saud Alhusaini,Saud Alhusaini,Yuri Milaneschi,Martina Papmeyer,Martina Papmeyer,Tomas Axelsson,Stefan Ehrlich,Stefan Ehrlich,Roberto Roiz-Santiañez,Bernd Kraemer,Asta Håberg,Hannah J. Jones,Hannah J. Jones,G. Bruce Pike,Dan J. Stein,Dan J. Stein,Allison Stevens,Janita Bralten,Meike W. Vernooij,Tamara B. Harris,Irina Filippi,A. Veronica Witte,A. Veronica Witte,Tulio Guadalupe,Katharina Wittfeld,Katharina Wittfeld,Thomas H. Mosley,James T. Becker,Nhat Trung Doan,Saskia P. Hagenaars,Yasaman Saba,Gabriel Cuellar-Partida,Najaf Amin,Saima Hilal,Saima Hilal,Kwangsik Nho,Nazanin Mirza-Schreiber,Konstantinos Arfanakis,Konstantinos Arfanakis,Diane M. Becker,David Ames,David Ames,Aaron Goldman,Phil Lee,Phil Lee,Dorret I. Boomsma,Dorret I. Boomsma,Simon Lovestone,Simon Lovestone,Sudheer Giddaluru,Sudheer Giddaluru,Stephanie Le Hellard,Stephanie Le Hellard,Manuel Mattheisen,Marc M. Bohlken,Dalia Kasperaviciute,Lianne Schmaal,Stephen M. Lawrie,Ingrid Agartz,Ingrid Agartz,Esther Walton,Esther Walton,Diana Tordesillas-Gutiérrez,Gareth E. Davies,Jean Shin,Jonathan C Ipser,Louis N. Vinke,Martine Hoogman,Tianye Jia,Ralph Burkhardt,Ralph Burkhardt,Marieke Klein,Fabrice Crivello,Deborah Janowitz,Owen Carmichael,Unn K. Haukvik,Unn K. Haukvik,Benjamin S. Aribisala,Benjamin S. Aribisala,Helena Schmidt,Lachlan T. Strike,Lachlan T. Strike,Ching-Yu Cheng,Shannon L. Risacher,Benno Pütz,Debra A. Fleischman,Amelia A. Assareh,Venkata S. Mattay,Randy L. Buckner,Patrizia Mecocci,Anders M. Dale,Sven Cichon,Sven Cichon,Marco P. Boks,Mar Matarin,Brenda W.J.H. Penninx,Vince D. Calhoun,Vince D. Calhoun,Vince D. Calhoun,M. Mallar Chakravarty,M. Mallar Chakravarty,Andre F. Marquand,Christine Macare,Shahrzad Kharabian Masouleh,Jaap Oosterlaan,Jaap Oosterlaan,Philippe Amouyel,Philippe Amouyel,Philippe Amouyel,Katrin Hegenscheid,Jerome I. Rotter,Andrew J. Schork,David C. Liewald,Greig I. de Zubicaray,Tien Yin Wong,Tien Yin Wong,Li Shen,Philipp G. Sämann,Henry Brodaty,Joshua L. Roffman,Eco J. C. de Geus,Eco J. C. de Geus,Magda Tsolaki,Susanne Erk,Kristel R. van Eijk,Gianpiero L. Cavalleri,Nic J.A. van der Wee,Andrew M. McIntosh,Randy L. Gollub,Kazima B. Bulayeva,Manon Bernard,Jennifer S. Richards,Jennifer S. Richards,Jayandra J. Himali,Jayandra J. Himali,Markus Loeffler,Nanda Rommelse,Wolfgang Hoffmann,Wolfgang Hoffmann,Lars T. Westlye,Lars T. Westlye,Maria C. Valdés Hernández,Narelle K. Hansell,Narelle K. Hansell,Theo G.M. van Erp,Christiane Wolf,John B.J. Kwok,John B.J. Kwok,John B.J. Kwok,Bruno Vellas,Andreas Heinz,Loes M. Olde Loohuis,Norman Delanty,Norman Delanty,Beng-Choon Ho,Christopher R.K. Ching,Christopher R.K. Ching,Elena Shumskaya,Baljeet Singh,Albert Hofman,Albert Hofman,Dennis van der Meer,Dennis van der Meer,Georg Homuth,Bruce M. Psaty,Mark E. Bastin,Grant W. Montgomery,Tatiana Foroud,Simone Reppermund,Jouke-Jan Hottenga,Jouke-Jan Hottenga,Andrew Simmons,Andrew Simmons,Andreas Meyer-Lindenberg,Wiepke Cahn,Christopher D. Whelan,Christopher D. Whelan,Marjolein M.J. van Donkelaar,Qiong Yang,Norbert Hosten,Robert C. Green,Anbupalam Thalamuthu,Sebastian Mohnke,Hilleke E. Hulshoff Pol,Honghuang Lin,Honghuang Lin,Clifford R. Jack,Peter R. Schofield,Peter R. Schofield,Thomas W. Mühleisen,Thomas W. Mühleisen,Pauline Maillard,Steven G. Potkin,Wei Wen,Evan Fletcher,Arthur W. Toga,Oliver Gruber,Matthew J. Huentelman,George Davey Smith,Lenore J. Launer,Lars Nyberg,Erik G. Jönsson,Erik G. Jönsson,Benedicto Crespo-Facorro,Nastassja Koen,Nastassja Koen,Douglas N. Greve,André G. Uitterlinden,Daniel R. Weinberger,Vidar M. Steen,Vidar M. Steen,Iryna O. Fedko,Iryna O. Fedko,Nynke A. Groenewold,Wiro J. Niessen,Wiro J. Niessen,Roberto Toro,Christophe Tzourio,William T. Longstreth,M. Kamran Ikram,Jordan W. Smoller,Jordan W. Smoller,Marie-José van Tol,Jessika E. Sussmann,Tomáš Paus,Herve Lemaitre,Matthias L. Schroeter,Matthias L. Schroeter,Bernard Mazoyer,Ole A. Andreassen,Ole A. Andreassen,Florian Holsboer,Chantal Depondt,Dick J. Veltman,Jessica A. Turner,Jessica A. Turner,Zdenka Pausova,Gunter Schumann,Daan van Rooij,Daan van Rooij,Srdjan Djurovic,Srdjan Djurovic,Ian J. Deary,Katie L. McMahon,Bertram Müller-Myhsok,Bertram Müller-Myhsok,Rachel M. Brouwer,Hilkka Soininen,Massimo Pandolfo,Thomas H. Wassink,Joshua W. Cheung,Thomas Wolfers,Jean-Luc Martinot,Marcel P. Zwiers,Matthias Nauck,Ingrid Melle,Ingrid Melle,Nicholas G. Martin,Ryota Kanai,Ryota Kanai,Eric Westman,René S. Kahn,René S. Kahn,Sanjay M. Sisodiya,Tonya White,Arvin Saremi,Hans van Bokhoven,Han G. Brunner,Han G. Brunner,Henry Völzke,Margaret J. Wright,Dennis van 't Ent,Dennis van 't Ent,Markus M. Nöthen,Roel A. Ophoff,Roel A. Ophoff,Jan K. Buitelaar,Guillén Fernández,Perminder S. Sachdev,Marcella Rietschel,Neeltje E.M. van Haren,Neeltje E.M. van Haren,Simon E. Fisher,Simon E. Fisher,Alexa S. Beiser,Alexa S. Beiser,Clyde Francks,Clyde Francks,Andrew J. Saykin,Karen A. Mather,Karen A. Mather,Nina Romanczuk-Seiferth,Catharina A. Hartman,Anita L. DeStefano,Anita L. DeStefano,Dirk J. Heslenfeld,Michael W. Weiner,Henrik Walter,Pieter J. Hoekstra,Paul A. Nyquist,Barbara Franke,David A. Bennett,Hans J. Grabe,Hans J. Grabe,Andrew D. Johnson,Christopher Chen,Christopher Chen,Cornelia M. van Duijn,Cornelia M. van Duijn,Oscar L. Lopez,Myriam Fornage,Joanna M. Wardlaw,Reinhold Schmidt,Charles DeCarli,Philip L. De Jager,Philip L. De Jager,Arno Villringer,Arno Villringer,Stéphanie Debette,Stéphanie Debette,Vilmundur Gudnason,Sarah E. Medland,Joshua M. Shulman,Paul M. Thompson,Sudha Seshadri,Sudha Seshadri,M. Arfan Ikram +375 more
TL;DR: This paper identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank.