22 Papers
48 Citations
Defeng Deng is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Pancreatic cancer & Biology. The author has an hindex of 15, co-authored 20 publications.
Chat about Author
Papers
An NF-κB pathway–mediated positive feedback loop amplifies Ras activity to pathological levels in mice
Jaroslaw Daniluk,Yan Liu,Defeng Deng,Jun Chu,Haojie Huang,Sebastian Gaiser,Zobeida Cruz-Monserrate,Huamin Wang,Baoan Ji,Baoan Ji,Craig D. Logsdon +10 more
TL;DR: The hypothesis that in the presence of oncogenic Ras, inflammatory stimuli trigger an NF-κB-mediated positive feedback mechanism involving Cox-2 that amplifies Ras activity to pathological levels is supported.
Cell surface lactate receptor GPR81 is crucial for cancer cell survival
Christina L. Roland,Thiruvengadam Arumugam,Defeng Deng,Shi He Liu,Bincy Philip,Sobeyda B. Gomez,William R. Burns,Vijaya Ramachandran,Huamin Wang,Zobeida Cruz-Monserrate,Craig D. Logsdon +10 more
TL;DR: Examination of GPR81 expression and function in cancer cells found that it was present in colon, breast, lung, hepatocellular, salivary gland, cervical, and pancreatic carcinoma cell lines, and in vivo, G PR81 expression levels correlated with the rate of pancreatic cancer tumor growth and metastasis.
259
Lipocalin-2 Promotes Pancreatic Ductal Adenocarcinoma by Regulating Inflammation in the Tumor Microenvironment.
Sobeyda B. Gomez-Chou,Agnieszka Katarzyna Swidnicka-Siergiejko,Agnieszka Katarzyna Swidnicka-Siergiejko,Niharika Badi,Niharika Badi,Myrriah Chavez-Tomar,Myrriah Chavez-Tomar,Gregory B. Lesinski,Tanios Bekaii-Saab,Matthew R. Farren,Thomas A. Mace,Carl Schmidt,Yan Liu,Defeng Deng,Rosa F. Hwang,Liran Zhou,Todd Moore,Deyali Chatterjee,Huamin Wang,Xiaohong Leng,Ralph B. Arlinghaus,Craig D. Logsdon,Zobeida Cruz-Monserrate +22 more
TL;DR: How LCN2 acts in the tumor microenvironment links obesity, inflammation, and PDAC development is revealed, with depletion of Lcn2 diminished extracellular matrix deposition, immune cell infiltration, PanIN formation, and tumor growth.
Mast Cells in Tumor Microenvironment Promotes the In Vivo Growth of Pancreatic Ductal Adenocarcinoma
David Z. Chang,Ying Ma,Baoan Ji,Huamin Wang,Defeng Deng,Yan Liu,James L. Abbruzzese,Yong-Jun Liu,Craig D. Logsdon,Patrick Hwu +9 more
TL;DR: Mast cells play an important role in PDAC growth and development in mouse models and are indicative of poor prognosis in humans, which makes them a potential novel therapeutic target.
138
New Blocking Antibodies against Novel AGR2–C4.4A Pathway Reduce Growth and Metastasis of Pancreatic Tumors and Increase Survival in Mice
Thiruvengadam Arumugam,Defeng Deng,Laura Bover,Huamin Wang,Craig D. Logsdon,Vijaya Ramachandran +5 more
TL;DR: These data support a model in which AGR2 binds and signals via C4.4A in an autocrine loop and promotes the growth of pancreas tumors in mice, and develop blocking mAbs against A GR2 and C 4.
74