Deborah K. West
New York State Department of Health
12 Papers
313 Citations
Deborah K. West is an academic researcher from New York State Department of Health. The author has contributed to research in topics: RNA & Intron. The author has an hindex of 9, co-authored 12 publications. Previous affiliations of Deborah K. West include Wadsworth Center.
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Papers
Structural requirements of double-stranded RNA for the activation of 2',5'-oligo(A) polymerase and protein kinase of interferon-treated HeLa cells.
TL;DR: Results indicate that a relatively long stretch of base pairs, uninterrupted by either a mismatch or a discontinuity in one of the complementary strands, is required for the activation of the two enzymes studied.
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Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities
Donald C. Porter,Elena Farmaki,Serena Altilia,Gary P. Schools,Deborah K. West,Mengqian Chen,Bey-Dih Chang,Anatoliy T. Puzyrev,Chang-uk Lim,Rebecca Rokow-Kittell,Lawrence T. Friedhoff,Athanasios G. Papavassiliou,S Kalurupalle,Gregory Hurteau,Jun Shi,Phil S. Baran,Balazs Gyorffy,Mark P. Wentland,Eugenia V. Broude,Hippokratis Kiaris,Igor B. Roninson +20 more
TL;DR: Microarray data analysis revealed striking correlations between CDK8 expression and poor survival in breast and ovarian cancers, and small-molecule compounds that inhibit damage-induced transcription downstream of p21 offered a promising approach to increasing the efficacy of cancer chemotherapy.
185
Characterization of the intron in the phage T4 thymidylate synthase gene and evidence for its self-excision from the primary transcript
TL;DR: The td gene contains a 735 bp open reading frame within its 1017 bp intron, and RNAase H studies and resistance of the cyclized intron to linearization by HeLa cell debranching enzyme suggest it to be circular.
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Processing of the intron-containing thymidylate synthase (td) gene of phage T4 is at the RNA level
Marlene Belfort,Joan Pedersen-Lane,Deborah K. West,Karen Ehrenman,Gladys F. Maley,Frederick K. Chu,Frank Maley +6 more
TL;DR: Analysis of td-encoded transcripts provides evidence in favor of maturation at the RNA level, consistent with an RNA processing model that would account for the direct gene transcript serving as precursor for both free intron RNA and a spliced mRNA that is colinear with the thymidylate synthase product.
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