Deanna Ojala
California Institute of Technology
24 Papers
478 Citations
Deanna Ojala is an academic researcher from California Institute of Technology. The author has contributed to research in topics: Mitochondrial DNA & RNA. The author has an hindex of 18, co-authored 24 publications.
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Papers
tRNA punctuation model of RNA processing in human mitochondria
TL;DR: It is proposed that the H strand is transcribed into a single polycistronic RNA molecule, which is processed later into mature species by precise endonucleolytic cleavages which occur, in most cases, immediately before and after a tRNA sequence.
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Nucleotide sequence of a region of human mitochondrial DNA containing the precisely identified origin of replication.
TL;DR: A fragment of HeLa cell mitochondrial DNA containing the origin of replication has been sequenced and the precise position of the origin has been identified by determining the nucleotide order in the 5′-end proximal portion of the heavy strand initiation fragment (7S DNA) and aligning the two sequences.
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Identification and partial characterization of multiple discrete polyadenylic acid containing RNA components coded for by HeLa cell mitochondrial DNA.
Deanna Ojala,Giuseppe Attardi +1 more
TL;DR: Together with the two mitochondrial rRNA species and with mitochondrial 4 S RNA, the eight poly(A)-containing RNA components, if distinct in sequence, would account for about 70% of the single-strand informational content of HeLa mitochondrial DNA.
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Expression of the mitochondrial genome in HeLa cells. X. Properties of mitochondrial polysomes.
Deanna Ojala,Giuseppe Attardi +1 more
TL;DR: In this article, the authors investigated the resistance of ribosomal polysomes to degradation by RNase in HeLa cell mitochondria and found that only a partial dissociation of the ribosomes into subunits and very little release of nascent chains were observed in the presence of even high concentrations of EDTA.
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Expression of the mitochondrial genome in HeLa cells. XIX. Occurrence in mitochondria of polyadenylic acid sequences, "free" and covalently linked to mitochondrial DNA-coded RNA.
Deanna Ojala,Giuseppe Attardi +1 more
TL;DR: The findings strongly suggest that poly(A) synthesis is in mitochondria, as in the nucleus, a post-transcriptional event, and that, in the presence of the drug, addition of newly synthesized poly (A) occurs to pre-existing precursor molecules.
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