David Whitmore
University College London
65 Papers
332 Citations
David Whitmore is an academic researcher from University College London. The author has contributed to research in topics: Circadian clock & Circadian rhythm. The author has an hindex of 29, co-authored 62 publications. Previous affiliations of David Whitmore include French Institute of Health and Medical Research & Max Planck Society.
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Papers
Light acts directly on organs and cells in culture to set the vertebrate circadian clock.
TL;DR: It is shown that the peripheral organ clocks of zebra fish are set by light–dark cycles in culture and that a zebrafish-derived cell line contains a circadian oscillator, which is also directly light entrained.
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Zebrafish Clock rhythmic expression reveals independent peripheral circadian oscillators
TL;DR: Cloned Clock in zebrafish shows that, in contrast to its mouse homologue, it is expressed with a pronounced circadian rhythm in the brain and in two defined pacemaker structures, the eye and the pineal gland, demonstrating that self-sustaining circadian oscillators exist in several vertebrate organs, as was previously reported for invertebrates.
370
A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes.
François Kroll,Gareth T. Powell,Marcus Ghosh,Gaia Gestri,Paride Antinucci,Timothy J Hearn,Hande Tunbak,Sumi Lim,Harvey W Dennis,Joseph M Fernandez,David Whitmore,David Whitmore,Elena Dreosti,Stephen W. Wilson,Ellen J. Hoffman,Jason Rihel +15 more
TL;DR: This work developed a simple sequencing-free tool to validate gRNAs and a highly effective CRISPR-Cas9 method capable of converting >90% of injected embryos directly into F0 biallelic knockouts, and demonstrates that F0 knockouts reliably recapitulate complex mutant phenotypes.
197
An extended family of novel vertebrate photopigments is widely expressed and displays a diversity of function
Wayne I. L. Davies,Wayne I. L. Davies,T. Katherine Tamai,Lei Zheng,Josephine K. Fu,Jason Rihel,Russell G. Foster,David Whitmore,Mark W. Hankins +8 more
TL;DR: This study has revealed a remarkable number and diversity of photopigments in zebrafish, the largest number so far discovered for any vertebrate, and Spectral and electrophysiological analyses of the new opsins demonstrate that they form functional photopIGments, each with unique chromophore-binding and wavelength specificities.
Light signaling to the zebrafish circadian clock by Cryptochrome 1a
TL;DR: It is shown that Cryptochrome 1a (Cry1a) plays a key role in light entrainment of the zebrafish clock, leading not only to entrainedment, but also to the establishment of a high-amplitude rhythm and even stopping of the clock under long photoperiods.
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