David M. Lee
Oregon Health & Science University
111 Papers
350 Citations
David M. Lee is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: Arthritis & Inflammatory arthritis. The author has an hindex of 50, co-authored 105 publications. Previous affiliations of David M. Lee include Boston Children's Hospital & Brigham and Women's Hospital.
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Papers
Platelets Amplify Inflammation in Arthritis via Collagen-Dependent Microparticle Production
Eric Boilard,Peter A. Nigrovic,Peter A. Nigrovic,Katherine Larabee,Gerald F. Watts,Jonathan S. Coblyn,Michael E. Weinblatt,Elena Massarotti,Eileen Remold-O'Donnell,Richard W. Farndale,Jerry Ware,David M. Lee +11 more
TL;DR: A previously unappreciated role for platelets and their activation-induced microparticles in inflammatory joint diseases is demonstrated and the collagen receptor glycoprotein VI is identified as a key trigger for platelet microparticle generation in arthritis pathophysiology.
Correction of a pathogenic gene mutation in human embryos
Hong Ma,Nuria Marti-Gutierrez,Sang-Wook Park,Jun Wu,Yeon-Mi Lee,Keiichiro Suzuki,Amy Koski,Dongmei Ji,Tomonari Hayama,Riffat Ahmed,Hayley Darby,Crystal Van Dyken,Ying Li,Eunju Kang,A. Reum Park,Daesik Kim,Sangtae Kim,Jianhui Gong,Ying Gu,Xun Xu,David Battaglia,Sacha A. Krieg,David M. Lee,Diana H. Wu,Don P. Wolf,Stephen B. Heitner,Juan Carlos Izpisua Belmonte,Paula Amato,Jin-Soo Kim,Sanjiv Kaul,Shoukhrat Mitalipov +30 more
TL;DR: The efficiency, accuracy and safety of the approach presented suggest that it has potential to be used for the correction of heritable mutations in human embryos by complementing preimplantation genetic diagnosis.
Mast Cells: A Cellular Link Between Autoantibodies and Inflammatory Arthritis
David M. Lee,Daniel S. Friend,Michael F. Gurish,Christophe Benoist,Diane Mathis,Michael B. Brenner +5 more
TL;DR: Two strains of mice deficient in mast cells were resistant to development of joint inflammation and that susceptibility was restored in the W/Wv strain by mast cell engraftment, suggesting mast cells may function as a cellular link between autoantibodies, soluble mediators, and other effector populations in inflammatory arthritis.
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Human Embryonic Stem Cells Derived by Somatic Cell Nuclear Transfer
Masahito Tachibana,Paula Amato,Michelle Sparman,Nuria Marti Gutierrez,Rebecca Tippner-Hedges,Hong Ma,Eunju Kang,Alimujiang Fulati,Hyo Sang Lee,Hathaitip Sritanaudomchai,Keith Masterson,Janine M. Larson,Deborah Eaton,K. Sadler-Fredd,David Battaglia,David M. Lee,Diana Wu,Jeffrey T. Jensen,Jeffrey T. Jensen,Phillip E. Patton,Sumita Gokhale,Richard L. Stouffer,Richard L. Stouffer,Don P. Wolf,Shoukhrat Mitalipov,Shoukhrat Mitalipov +25 more
TL;DR: Gene expression and differentiation profiles in human NT-ESCs were similar to embryo-derived ESCs, suggesting efficient reprogramming of somatic cells to a pluripotent state.
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Arthritis Critically Dependent on Innate Immune System Players
Hong Ji,Koichiro Ohmura,Koichiro Ohmura,Umar Mahmood,David M. Lee,Frans M. A. Hofhuis,Susan A. Boackle,Kazue Takahashi,V. Michael Holers,Mark Walport,Craig Gerard,Alan Ezekowitz,Michael C. Carroll,Michael B. Brenner,Ralph Weissleder,J. Sjef Verbeek,Veronique Duchatelle,Claude Degott,Christophe Benoist,Christophe Benoist,Christophe Benoist,Diane Mathis,Diane Mathis,Diane Mathis +23 more
TL;DR: It is suggested that autoimmune disease, even one that is organ specific, can occur when mobilization of an adaptive immune response results in runaway activation of the innate response.
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