David J. Roberts
NHS Blood and Transplant
303 Papers
1.6K Citations
David J. Roberts is an academic researcher from NHS Blood and Transplant. The author has contributed to research in topics: Medicine & Plasmodium falciparum. The author has an hindex of 53, co-authored 274 publications. Previous affiliations of David J. Roberts include John Radcliffe Hospital & Churchill Hospital.
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Papers
Genomic atlas of the human plasma proteome.
Benjamin B. Sun,Joseph C. Maranville,James E. Peters,James E. Peters,David Stacey,James R Staley,James A. Blackshaw,Stephen Burgess,Tao Jiang,Ellie Paige,Ellie Paige,Praveen Surendran,Clare Oliver-Williams,Mihir A Kamat,Bram P. Prins,Sheri K. Wilcox,Erik S Zimmerman,An Chi,Narinder Bansal,Narinder Bansal,Sarah L. Spain,Angela M. Wood,Nicholas W. Morrell,Nicholas W. Morrell,John Bradley,Nebojsa Janjic,David J. Roberts,David J. Roberts,Willem H. Ouwehand,John A. Todd,Nicole Soranzo,Karsten Suhre,Dirk S. Paul,Caroline S. Fox,Robert M. Plenge,John Danesh,John Danesh,Heiko Runz,Adam S. Butterworth +38 more
TL;DR: The genetic architecture of the human plasma proteome in healthy blood donors from the INTERVAL study is characterized, and it is shown that protein quantitative trait loci overlap with gene expression quantitative traits, as well as with disease-associated loci, and evidence that protein biomarkers have causal roles in disease is found.
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease
William J. Astle,Heather Elding,Heather Elding,Tao Jiang,Dave Allen,Dace Ruklisa,Dace Ruklisa,Alice L. Mann,Daniel Mead,Heleen J. Bouman,Fernando Riveros-Mckay,Myrto Kostadima,Myrto Kostadima,Myrto Kostadima,John J. Lambourne,John J. Lambourne,Suthesh Sivapalaratnam,Suthesh Sivapalaratnam,Kate Downes,Kate Downes,Kousik Kundu,Kousik Kundu,Lorenzo Bomba,Kim Berentsen,John Bradley,John Bradley,Louise C. Daugherty,Louise C. Daugherty,Olivier Delaneau,Kathleen Freson,Stephen F. Garner,Stephen F. Garner,Luigi Grassi,Luigi Grassi,Jose A. Guerrero,Jose A. Guerrero,Matthias Haimel,Eva M. Janssen-Megens,Anita Kaan,Mihir A Kamat,Bowon Kim,Amit Mandoli,Jonathan Marchini,Jonathan Marchini,Joost H.A. Martens,Stuart Meacham,Stuart Meacham,Karyn Megy,Karyn Megy,Jared O'Connell,Jared O'Connell,Romina Petersen,Romina Petersen,Nilofar Sharifi,S.M. Sheard,James R Staley,Salih Tuna,Martijn van der Ent,Klaudia Walter,Shuang-Yin Wang,Eleanor Wheeler,Steven P. Wilder,Valentina Iotchkova,Valentina Iotchkova,Carmel Moore,Jennifer G. Sambrook,Jennifer G. Sambrook,Hendrik G. Stunnenberg,Emanuele Di Angelantonio,Emanuele Di Angelantonio,Emanuele Di Angelantonio,Stephen Kaptoge,Stephen Kaptoge,Taco W. Kuijpers,Enrique Carrillo-de-Santa-Pau,David Juan,Daniel Rico,Alfonso Valencia,Lu Chen,Lu Chen,Bing Ge,Louella Vasquez,Tony Kwan,Diego Garrido-Martín,Stephen Watt,Ying Yang,Roderic Guigó,Stephan Beck,Dirk S. Paul,Dirk S. Paul,Tomi Pastinen,David Bujold,Guillaume Bourque,Mattia Frontini,Mattia Frontini,Mattia Frontini,John Danesh,David J. Roberts,David J. Roberts,Willem H. Ouwehand,Adam S. Butterworth,Adam S. Butterworth,Adam S. Butterworth,Nicole Soranzo +103 more
TL;DR: A genome-wide association analysis in the UK Biobank and INTERVAL studies is performed, providing evidence of shared genetic pathways linking blood cell indices with complex pathologies, including autoimmune diseases, schizophrenia, and coronary heart disease and evidence suggesting previously reported population associations betweenBlood cell indices and cardiovascular disease may be non-causal.
1.3K
Switches in expression of Plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes.
Joseph D. Smith,Chetan E. Chitnis,Alistar G. Craig,David J. Roberts,Diana E. Hudson-Taylor,David S. Peterson,Robert Pinches,Chris I. Newbold,Louis H. Miller +8 more
TL;DR: It is shown that expression of variant antigenic determinants is correlated with expression of individual members of a large, multigene family named var, which is consistent with the involvement of var genes in antigenic variation and binding to endothelium.
1K
SARS-CoV-2 evolution during treatment of chronic infection.
Steven Kemp,Dami A. Collier,Dami A. Collier,Rawlings Datir,Isabella Ferreira,Salma Gayed,Aminu S Jahun,Myra Hosmillo,Chloe Rees-Spear,Petra Mlcochova,Ines Ushiro Lumb,David J. Roberts,Anita Chandra,Nigel J. Temperton,Katherine Sharrocks,Elizabeth Blane,Yorgo Modis,Yorgo Modis,Kendra E. Leigh,Kendra E. Leigh,John A. G. Briggs,Marit J. van Gils,Kenneth G. C. Smith,John Bradley,Chris Smith,Rainer Doffinger,Lourdes Ceron-Gutierrez,Gabriela Barcenas-Morales,David D. Pollock,Richard A. Goldstein,Anna Smielewska,Jordan P. Skittrall,Theodore Gouliouris,Ian Goodfellow,Effrossyni Gkrania-Klotsas,Christopher J. R. Illingworth,Laura E. McCoy,Ravindra K. Gupta +37 more
TL;DR: In this paper, the authors report chronic SARS-CoV-2 with reduced sensitivity to neutralizing antibodies in an immune suppressed individual treated with convalescent plasma, generating whole genome ultradeep sequences over 23 time points spanning 101 days.
Plasmodium falciparum-infected erythrocytes modulate the maturation of dendritic cells.
Britta C. Urban,David J. P. Ferguson,Arnab Pain,Nick Willcox,Magdalena Plebanski,Jonathan M. Austyn,David J. Roberts +6 more
TL;DR: It is shown that intact malaria-infected erythrocytes adhere to dendritic cells, inhibit the maturation of dendedritic cells and subsequently reduce their capacity to stimulate T cells, demonstrating both a novel mechanism by which malaria parasites induce immune dysregulation and a functional role beyond endothelial adhesion for the adhesive phenotypes expressed at the surface of infected ery Throcytes.
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