Danni Liu
Princeton University
11 Papers
87 Citations
Danni Liu is an academic researcher from Princeton University. The author has contributed to research in topics: Biology & Neurite. The author has an hindex of 8, co-authored 10 publications.
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Papers
Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities
Benfang Ruan,Kevin Pong,Flora Jow,Mark R. Bowlby,Robert A. Crozier,Danni Liu,Shi Liang,Yi Chen,Mary Lynn T. Mercado,Xidong Feng,Frann Bennett,David von Schack,Leonard A. McDonald,Margaret M. Zaleska,Andrew R. Wood,Peter H. Reinhart,Ronald L. Magolda,Jerauld S. Skotnicki,Menelas N. Pangalos,Frank E. Koehn,Guy T. Carter,Magid Abou-Gharbia,Edmund I. Graziani +22 more
TL;DR: Modification at the mammalian target of rapamycin (mTOR) binding region yields immunophilin ligands, WYE-592 and ILS-920, with potent neurotrophic activities in cortical neuronal cultures, efficacy in a rodent model for ischemic stroke, and significantly reduced immunosuppressive activity.
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Ischemia-stimulated neurogenesis is regulated by proliferation, migration, differentiation and caspase activation of hippocampal precursor cells
TL;DR: Surprisingly, it was found that ischemic injury induced activation of caspase-3, not only in the CA1 region as expected, but also in the dentate subgranular zone (SGZ), which was co-localized with an early neuronal marker, suggesting that casp enzyme-mediated apoptosis could mediate the loss of neurogenic cells in the SGZ.
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Temporal assessment of caspase activation in experimental models of focal and global ischemia
TL;DR: Levels of caspase-3 enzyme activity peaked at 12 h in hippocampal tissue extracts following global ischemia in gerbils, and strong caspasing-3 immunoreactivity was also detected in the subgranular zone of the dentate gyrus, a known region of ischemic-induced neurogenesis.
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Screening of immunophilin ligands by quantitative analysis of neurofilament expression and neurite outgrowth in cultured neurons and cells
Danni Liu,H. Beal McIlvain,Myles Fennell,John Dunlop,Andrew Wood,Margaret M. Zaleska,Edmund I. Graziani,Kevin Pong +7 more
TL;DR: The results showed that all immunophilin ligands, in a concentration-dependent manner, significantly increased neuronal survival and neurite outgrowth, when compared to control cultures.
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3-normeridamycin: a potent non-immunosuppressive immunophilin ligand is neuroprotective in dopaminergic neurons.
TL;DR: 3-Normeridamycin (1), isolated from fermentation extracts of the soil actinomycete Streptomyces sp.