Daniel P. Cardinali
Pontifical Catholic University of Argentina
508 Papers
5.5K Citations
Daniel P. Cardinali is an academic researcher from Pontifical Catholic University of Argentina. The author has contributed to research in topics: Melatonin & Circadian rhythm. The author has an hindex of 70, co-authored 496 publications. Previous affiliations of Daniel P. Cardinali include Universidad del Salvador & Complutense University of Madrid.
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Papers
Melatonin: Nature's most versatile biological signal?
Seithikurippu R. Pandi-Perumal,V. Srinivasan,Georges J.M. Maestroni,Daniel P. Cardinali,Burkhard Poeggeler,Rüdiger Hardeland +5 more
TL;DR: Melatonin is principally secreted at night and is centrally involved in sleep regulation, as well as in a number of other cyclical bodily activities, and its sleep-facilitating properties have been found to be useful for treating insomnia symptoms in elderly and depressive patients.
934
Melatonin—A pleiotropic, orchestrating regulator molecule
Rüdiger Hardeland,Daniel P. Cardinali,Venkatramanujam Srinivasan,D. Warren Spence,Gregory M. Brown,Seithikurippu R. Pandi-Perumal +5 more
TL;DR: Control of electron flux, prevention of bottlenecks in the respiratory chain and electron leakage contribute to the avoidance of damage by free radicals and seem to be important in neuroprotection, inflammatory diseases and, presumably, aging.
858
Physiological effects of melatonin: role of melatonin receptors and signal transduction pathways.
Seithikurippu R. Pandi-Perumal,Ilya Trakht,Venkataramanujan Srinivasan,D. Warren Spence,Georges J.M. Maestroni,Nava Zisapel,Daniel P. Cardinali +6 more
TL;DR: The evidence concerning melatonin receptors and signal transduction pathways in various organs is reviewed and their relevance to circadian physiology and pathogenesis of certain human diseases, with a focus on the brain, the cardiovascular and immune systems, and cancer is considered.
795
International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, Classification, and Pharmacology of G Protein-Coupled Melatonin Receptors
Margarita L. Dubocovich,Philippe Delagrange,Diana N. Krause,David Sugden,Daniel P. Cardinali,James Olcese +5 more
TL;DR: The steps taken since melatonin's discovery by Aaron Lerner in 1958 are summarized to functionally characterize, clone, and localize receptors in mammalian tissues, as well as current efforts to discover and develop ligands for treatment of a number of illnesses.
594
Dim light melatonin onset (DLMO): A tool for the analysis of circadian phase in human sleep and chronobiological disorders
Seithikurippu R. Pandi-Perumal,Marcel Smits,Warren Spence,Warren Spence,Venkataramanujan Srinivasan,Daniel P. Cardinali,Alan D. Lowe,Leonid Kayumov +7 more
TL;DR: The dim light melatonin onset or DLMO marker is useful for determining whether an individual is entrained to a 24-h light/dark (LD) cycle or is in a free-running state, and is also useful for assessing phase delays or advances of rhythms in entrained individuals.
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