Daniel O'Toole
National University of Ireland, Galway
76 Papers
114 Citations
Daniel O'Toole is an academic researcher from National University of Ireland, Galway. The author has contributed to research in topics: Mesenchymal stem cell & Lung injury. The author has an hindex of 21, co-authored 56 publications. Previous affiliations of Daniel O'Toole include University College Dublin & Beaumont Hospital.
Chat about Author
Papers
Mesenchymal stem cells enhance recovery and repair following ventilator-induced lung injury in the rat
Gerard F. Curley,Mairead Hayes,Bilal Ansari,Georgina Shaw,Aideen E. Ryan,Frank Barry,Timothy O'Brien,Daniel O'Toole,John G. Laffey +8 more
TL;DR: MSC therapy enhances lung repair following VILI via a paracrine mechanism that may be keratinocyte growth factor-dependent and not seen with non-stem cells (ie, rat fibroblasts).
273
β-Glucan extracts from the same edible shiitake mushroom Lentinus edodes produce differential in-vitro immunomodulatory and pulmonary cytoprotective effects — Implications for coronavirus disease (COVID-19) immunotherapies
Emma J. Murphy,Claire Masterson,Emanuele Rezoagli,Daniel O'Toole,Ian Major,Gary D. Stack,Mark Lynch,John G. Laffey,Neil J. Rowan +8 more
TL;DR: Significant physicochemical differences between Lentinan extracts are demonstrated, which produce differential in vitro immunomodulatory and pulmonary cytoprotective effects that may also have positive relevance to candidate COVID-19 therapeutics targeting cytokine storm.
129
Hypercapnic acidosis attenuates pulmonary epithelial wound repair by an NF-kappaB dependent mechanism.
Daniel O'Toole,Patrick Hassett,Maya Contreras,Brendan D. Higgins,Scott McKeown,Daniel F. McAuley,Timothy O'Brien,John G. Laffey +7 more
TL;DR: Hypercapnic acidosis inhibits pulmonary epithelial wound healing by reducing cell migration via an NF-κB dependent mechanism that may involve alterations in matrix metalloproteinase activity.
118
Lentiviral vector mediated modification of mesenchymal stem cells & enhanced survival in an in vitro model of ischaemia
Lisa M. McGinley,Jill McMahon,Padraig Strappe,Frank Barry,Mary Murphy,Daniel O'Toole,Timothy O'Brien +6 more
TL;DR: It is suggested that lentiviral vector transduction can facilitate sustained therapeutic gene expression, providing an efficient tool for ex vivo MSC modification and this finding may have considerable significance in improving the efficacy of MSC-based therapies.
Mesenchymal Stem Cell Survival in the Infarcted Heart Is Enhanced by Lentivirus Vector-Mediated Heat Shock Protein 27 Expression
Lisa M. McGinley,Jill McMahon,Alessia Stocca,Aoife Duffy,Aidan Flynn,Daniel O'Toole,Timothy O'Brien +6 more
TL;DR: Ex vivo genetic modification-specifically Hsp27 overexpression-offers the possibility of enhancing the efficacy of MSC therapy in MI, and decreased apoptosis in the infarcted tissue and improved cardiac function was observed in the HSp27 group, enhancing the therapeutic effect of M SCs.
99