Daniel Lundell
Merck & Co.
79 Papers
914 Citations
Daniel Lundell is an academic researcher from Merck & Co.. The author has contributed to research in topics: Receptor & Chemistry. The author has an hindex of 29, co-authored 79 publications. Previous affiliations of Daniel Lundell include Schering-Plough.
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Papers
•Journal Article
Endocannabinoid 2-arachidonyl glycerol is a full agonist through human type 2 cannabinoid receptor: antagonism by anandamide.
TL;DR: It was shown that both endocannabinoids bound hCB2 with similar affinity and that the cannabinoids acted as full agonists in stimulating [(35)S]GTPgammaS exchange, although 2-AG was 3-fold more potent than anandamide (EC(50) = 38.9 +/- 3.1 and 121 +/- 29 nM, respectively).
381
Crystal structure of a complex between interferon-γ and its soluble high-affinity receptor
Mark R. Walter,William T. Windsor,Tattanahalli L. Nagabhushan,Daniel Lundell,Charles A. Lunn,Paul J. Zauodny,Satwant K. Narula +6 more
TL;DR: The crystal structure of interferon-γ bound to the extracellular fragment of its high-affinity cellsurface receptor reveals the first view of a class-2 cytokine receptor-ligand complex.
372
Short-chain fatty acids act as antiinflammatory mediators by regulating prostaglandin E2 and cytokines.
Mary Ann Cox,James V. Jackson,Michaela C. Stanton,Alberto Rojas-Triana,Loretta A. Bober,Maureen Laverty,Xiaoxin Yang,Feng Zhu,Jianjun Liu,Suke Wang,Frederick J. Monsma,Galya Vassileva,Maureen Maguire,Eric A. Gustafson,Marvin L. Bayne,Chuan-Chu Chou,Daniel Lundell,Chung-Her Jenh +17 more
TL;DR: It is shown that SCFAs can induce human monocyte release of PGE2 and that this effect can be enhanced in the presence of lipopolysaccharide (LPS), and it is demonstrated that P GE2 production induced by SCFA was inhibited by pertussis toxin, suggesting the involvement of a receptor-mediated mechanism.
344
Purification of ADAM 10 from bovine spleen as a TNFα convertase
Charles A. Lunn,Xuedong Fan,Barbara Dalie,Kenneth Miller,Paul J. Zavodny,Satwant K. Narula,Daniel Lundell +6 more
TL;DR: A protease with characteristics of TNFα convertase from bovine spleen membranes is purified and cloned ADAM 10 mediates proTNFα processing in a processing‐incompetent cell line.
141
Patent
3,4-DI-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
Arthur G. Taveras,Cynthia J. Aki,Jianping Chao,Michael P. Dwyer,Jianhua Chao,Younong Yu,J. Robert Merritt,Purakkattle Biju,James Jakway,Gaifa Lai,Minglang Wu,Evan A. Hecker,Daniel Lundell,Jay S. Fine +13 more
- 30 Jul 2003
TL;DR: In this article, novel compounds of the formula (I) or a pharmaceutically acceptable salt or solvate thereof were presented. And the treatment of chemokine-mediated diseases using compounds of formula (II) was described.
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