Conor O'Keane
Mater Misericordiae University Hospital
44 Papers
484 Citations
Conor O'Keane is an academic researcher from Mater Misericordiae University Hospital. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 18, co-authored 39 publications. Previous affiliations of Conor O'Keane include Mater Misericordiae Hospital & University College Dublin.
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Papers
2D-DIGE as a strategy to identify serum markers for the progression of prostate cancer.
Jennifer C. Byrne,Michelle Downes,Niaobh O'Donoghue,Conor O'Keane,Amanda O'Neill,Yue Fan,John M. Fitzpatrick,Michael J. Dunn,R. William G. Watson +8 more
TL;DR: In this article, two proteins, pigment epithelium-derived factor (PEDF) and zinc-alpha2-glycoprotein (ZAG), have been used for early stage prostate cancer diagnosis.
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Hemochromatosis in Ireland and HFE.
TL;DR: The finding that 93% of hereditary hemochromatosis patients who fulfil standard diagnostic criteria are homozygous for the C282Y mutation provides clear evidence that this mutation is strongly associated with hereditary hemosynthesis.
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Net1 and Myeov: computationally identified mediators of gastric cancer.
J Leyden,David W. Murray,Alan C. Moss,M Arumuguma,E Doyle,G. McEntee,Conor O'Keane,Peter Doran,Padraic MacMathuna +8 more
TL;DR: Functional studies highlight a putative role for NET1 and Myeov in the development and progression of gastric cancer, evidenced by their role in promoting invasion and proliferation, key phenotypic hallmarks of cancer cells.
Lipoxin A4 and Aspirin-Triggered 15-Epi-Lipoxin A4 Antagonize TNF-α-Stimulated Neutrophil-Enterocyte Interactions In Vitro and Attenuate TNF-α-Induced Chemokine Release and Colonocyte Apoptosis in Human Intestinal Mucosa Ex Vivo
Jason Goh,Alan W. Baird,Conor O'Keane,R. William G. Watson,David C. Cottell,Giovanni Bernasconi,Nicos A. Petasis,Catherine Godson,Catherine Godson,Hugh R. Brady,Hugh R. Brady,Padraic MacMathuna +11 more
TL;DR: The data demonstrate that lipoxins and aspirin-triggered 15-epi-LXA4 are potent antagonists of TNF-α-mediated neutrophil-enterocyte interactions in vitro, attenuate TNF’s chemokine release and colonocyte apoptosis, and are protective against TNF -α-induced morphological disruption in human colonic strips ex vivo.
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Cyclin E1 Is Amplified and Overexpressed in Osteosarcoma
William W. Lockwood,Deirdre Stack,Thomas Morris,David Grehan,Conor O'Keane,Greg L. Stewart,Joanna Cumiskey,Wan L. Lam,Jeremy A. Squire,David Thomas,Maureen J. O'Sullivan +10 more
TL;DR: Using a whole-genome tiling path array for comparative genomic hybridization analysis and correlation of the copy number data with preexisting expression data for these genes yielded not only targets known to be important in osteosarcoma but also novel targets, notably cyclin E1.
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