Claudine Isaacs
Georgetown University
332 Papers
1.7K Citations
Claudine Isaacs is an academic researcher from Georgetown University. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 74, co-authored 286 publications. Previous affiliations of Claudine Isaacs include Georgetown University Medical Center & University of Washington.
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Papers
Prophylactic Oophorectomy in Carriers of BRCA1 or BRCA2 Mutations
Timothy R. Rebbeck,Henry T. Lynch,Susan L. Neuhausen,Steven A. Narod,Laura J. van't Veer,Judy Garber,Gareth Evans,Claudine Isaacs,Mary B. Daly,Ellen T. Matloff,Olufunmilayo I. Olopade,Barbara L. Weber +11 more
TL;DR: Bilateral prophylactic oophorectomy reduces the risk of coelomic epithelial cancer and breast cancer in women with BRCA1 or BRCa2 mutations.
1.5K
Association of Risk-Reducing Surgery in BRCA1 or BRCA2 Mutation Carriers With Cancer Risk and Mortality
Susan M. Domchek,Tara M. Friebel,Christian F. Singer,D. Gareth Evans,Henry T. Lynch,Claudine Isaacs,Judy Garber,Susan L. Neuhausen,Ellen T. Matloff,Rosalind A. Eeles,Gabriella Pichert,Laura Van T'veer,Nadine Tung,Jeffrey N. Weitzel,Fergus J. Couch,Wendy S. Rubinstein,Wendy S. Rubinstein,Patricia A. Ganz,Mary B. Daly,Olufunmilayo I. Olopade,Gail E. Tomlinson,Joellen M. Schildkraut,Joanne L. Blum,Timothy R. Rebbeck +23 more
TL;DR: Among a cohort of women with BRCa1 and BRCA2 mutations, the use of risk-reducing mastectomy was associated with a lower risk of breast cancer, first diagnosis of breastcancer, all-cause mortality, breast cancer-specific mortality, and ovarian cancer- specific mortality.
1.4K
Effect of screening on ovarian cancer mortality: the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Randomized Controlled Trial.
Saundra S. Buys,Edward E. Partridge,Amanda Black,Christine Cole Johnson,Lois Lamerato,Claudine Isaacs,Douglas J. Reding,Robert T. Greenlee,Lance A. Yokochi,Bruce Kessel,E. David Crawford,Timothy R. Church,Gerald L. Andriole,Joel L. Weissfeld,Mona N. Fouad,David Chia,Barbara O'Brien,Lawrence R. Ragard,Jonathan D. Clapp,Joshua M. Rathmell,Thomas L. Riley,Patricia Hartge,Paul F. Pinsky,Claire S. Zhu,Grant Izmirlian,Barnett S. Kramer,Anthony B. Miller,Jian Lun Xu,Philip C. Prorok,John K. Gohagan,Christine D. Berg +30 more
TL;DR: Among women in the general US population, simultaneous screening with CA-125 and transvaginal ultrasound compared with usual care did not reduce ovarian cancer mortality.
Bilateral Prophylactic Mastectomy Reduces Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers: The PROSE Study Group
Timothy R. Rebbeck,Tara M. Friebel,Henry T. Lynch,Susan L. Neuhausen,Laura van 't Veer,Judy Garber,G Evans,Steven A. Narod,Claudine Isaacs,Ellen T. Matloff,Mary B. Daly,Olufunmilayo I. Olopade,Barbara L. Weber +12 more
TL;DR: Bilateral prophylactic mastectomy reduces the risk of breast cancer in women with BRCA1/2 mutations by approximately 90%.
1.1K
Prostate Cancer Screening in the Randomized Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial: Mortality Results after 13 Years of Follow-up
Gerald L. Andriole,E. David Crawford,Robert L. Grubb,Saundra S. Buys,David Chia,Timothy R. Church,Mona N. Fouad,Claudine Isaacs,Paul A. Kvale,Douglas J. Reding,Joel L. Weissfeld,Lance A. Yokochi,Barbara O'Brien,Lawrence R. Ragard,Jonathan D. Clapp,Joshua M. Rathmell,Thomas L. Riley,Ann W. Hsing,Grant Izmirlian,Paul F. Pinsky,Barnett S. Kramer,Barnett S. Kramer,Anthony B. Miller,John K. Gohagan,Philip C. Prorok +24 more
TL;DR: There was no evidence of a mortality benefit for organized annual screening in the PLCO trial compared with opportunistic screening, which forms part of usual care, and there was no apparent interaction with age, baseline comorbidity, or pretrial PSA testing.