Ciprian P. Gheorghe
Loma Linda University
28 Papers
197 Citations
Ciprian P. Gheorghe is an academic researcher from Loma Linda University. The author has contributed to research in topics: Regulation of gene expression & Fetus. The author has an hindex of 12, co-authored 23 publications. Previous affiliations of Ciprian P. Gheorghe include Yale University.
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Papers
Early gestational mesenchymal stem cell secretome attenuates experimental bronchopulmonary dysplasia in part via exosome-associated factor TSG-6
Sushma Chaubey,Sam Thueson,Devasena Ponnalagu,Mohammad Afaque Alam,Ciprian P. Gheorghe,Zubair H. Aghai,Harpreet Singh,Vineet Bhandari +7 more
TL;DR: Preterm hUC-derived MSC-CM EXO alleviates hyperoxia-induced BPD and its associated pathologies, in part, via exosomal factor TSG-6, an immunomodulatory glycoprotein, in EXO.
Gene expression in the placenta: maternal stress and epigenetic responses
TL;DR: Although each individual maternal stress is characterized by up- or down-regulation of specific genes in the placenta, functional analysis reveals some patterns of gene expression common to the several forms of stress.
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Placental Gene Expression Responses to Maternal Protein Restriction in the Mouse
TL;DR: It is observed that negative regulators of cell growth and metabolism in conjunction with genes involved in epigenesis were up-regulated, suggesting that protein deprivation may contribute to growth restriction and long-term epigenetic changes in stressed tissues and organs.
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Gene expression patterns in the hypoxic murine placenta: a role in epigenesis?
TL;DR: The observation that Hypoxia upregulates reactive oxygen species metabolism, in conjunction with DNA methylation enzymes, suggests that hypoxia may contribute to long-term epigenetic changes in stressed fetal tissues and organs.
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Antenatal maternal hypoxic stress: adaptations in fetal lung Renin-Angiotensin system.
TL;DR: The hypothesis that antenatal maternal hypoxia is associated with alterations in gene and protein expression of the pulmonary renin-angiotensin system, which may play an important role in pulmonary disorders in the offspring is tested.
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