Christopher Milton
National Institute for Medical Research
6 Papers
1 Citations
Christopher Milton is an academic researcher from National Institute for Medical Research. The author has contributed to research in topics: Hepatic stellate cell & Neuregulin. The author has an hindex of 3, co-authored 4 publications.
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Papers
Transcriptional repression coordinates the temporal switch from motor to serotonergic neurogenesis
John Jacob,Anna L M Ferri,Christopher Milton,Fabrice Prin,Patrick Pla,Wei Lin,Anthony Gavalas,Siew-Lan Ang,James Briscoe +8 more
TL;DR: It is found that the forkhead transcription factor Foxa2, acting in progenitors, is essential for the transition from VMN to serotonergic neurogenesis, and the subsequent differentiation of centralserotonergic neurons required both the suppression of VMN neuroGenesis and the induction of downstream intrinsic determinants of seroton allergic identity by Foxa1.
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Repression of the proneural factor Ascl1 by retinoid signalling restricts neuronal fate choices in the ventral spinal cord
John Jacob,Steven Moore,Christopher Milton,Rosa Gonzalez-Quevedo,Javier Terriente,James Briscoe +5 more
TL;DR: It is suggested that Fezf2 may be a key regulator of neural progenitor cell development in response to immune insult by time-lapse imaging using a SNAP-tagged HMGB1 construct and by immunocytochemistry.
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Correction: Nuclear FGFR1 promotes pancreatic stellate cell-driven invasion through up-regulation of Neuregulin 1
Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrain.
John Jacob,Robert Storm,Diogo S. Castro,Christopher Milton,Patrick Pla,François Guillemot,Carmen Birchmeier,James Briscoe +7 more
TL;DR: The zinc-finger transcription factor, Insm1, is identified as a crucial mediator of the differentiation of both serotonergic and noradrenergic subtypes, and in particular the acquisition of their neurotransmitter phenotype.
Retinoid Acid Specifies Neuronal Identity through Graded Expression of Ascl1
John Jacob,Jennifer H. Kong,Steven Moore,Christopher Milton,Noriaki Sasai,Rosa Gonzalez-Quevedo,Javier Terriente,Itaru Imayoshi,Ryoichiro Kageyama,David G. Wilkinson,Bennett G. Novitch,James Briscoe +11 more
TL;DR: Retinoids, via Notch signaling, control the expression level in progenitors of the transcription factor Ascl1, which selects serotonergic and V3 neuronal identities in a dose-dependent manner, suggesting quantitative differences in the expression of a single component of a transcriptional code can select distinct cell fates.