Christopher J. Leitheiser
University of Virginia
19 Papers
141 Citations
Christopher J. Leitheiser is an academic researcher from University of Virginia. The author has contributed to research in topics: Immune system & Chemistry. The author has an hindex of 10, co-authored 12 publications. Previous affiliations of Christopher J. Leitheiser include University of Minnesota & Ironwood Pharmaceuticals.
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Papers
Discovery and Characterization of a Potent Interleukin-6 Binding Peptide with Neutralizing Activity In Vivo.
Sheila Ranganath,Ashok Bhandari,Nicole Avitahl-Curtis,Jaimee McMahon,Derek Wachtel,Jenny Zhang,Christopher J. Leitheiser,Sylvie G. Bernier,Guang Liu,Tran Trung Tran,Herodion Celino,Jenny Tobin,Joon Jung,Hong Zhao,Katie E. Glen,Chris Graul,Aliesha Griffin,Schairer Wayne C,Carolyn S. Higgins,Tammi L. Reza,Eva Mowe,Sam Rivers,Sonya Scott,Alex W. Monreal,Courtney Shea,Greg T. Bourne,Casey Coons,Adaline Smith,Kim Tang,Ramya A. Mandyam,Jaime L. Masferrer,David R. Liu,Dinesh V. Patel,Angelika Fretzen,Craig A. Murphy,G. Todd Milne,Mark L. Smythe,Kenneth E. Carlson +37 more
TL;DR: Parenteral administration of PN-2921 to mice and cynomolgus monkeys potently inhibited IL-6-induced biomarker responses, with significant reductions in the acute inflammatory phase proteins, serum amyloid A (SAA) and C-reactive protein (CRP).
Alteration of the selectivity of DNA cleavage by a deglycobleomycin analogue containing a trithiazole moiety.
Craig J. Thomas,Michael M. McCormick,Corine Vialas,Zhi Fu Tao,Christopher J. Leitheiser,Michael J. Rishel,Xihan Wu,Sidney M. Hecht +7 more
TL;DR: A trithiazole-containing deglycoBLM analogue was synthesized and tested for its ability to relax supercoiled DNA and cleave linear duplex DNA in a sequence-selective fashion and showed a strong preference for cleavage at two 5'-GT-3' sites when a 5'-(32)P end-labeled DNA duplex was used as a substrate.
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Solid-Phase Synthesis of Bleomycin Group Antibiotics. Elaboration of Deglycobleomycin A5
TL;DR: In this article, solid-phase syntheses of two deglycobleomycin A5 analogues were achieved using a commercially available polystyrene resin containing triphenylmethyl-linked spermidine, which was deblocked and released from the resin, analyzed, and purified by C18 reversed phase HPLC and characterized by high-field 1H NMR spectroscopy and mass spectrometry.
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Biochemical evaluation of a 108-member deglycobleomycin library: viability of a selection strategy for identifying bleomycin analogues with altered properties.
Qian Ma,Zhidong Xu,Benjamin R. Schroeder,Wenyue Sun,Fang Wei,Shigeki Hashimoto,Kazuhide Konishi,Christopher J. Leitheiser,Sidney M. Hecht +8 more
TL;DR: Insight is provided into structural elements within BLM that control DNA and RNA cleavage and regarding the practicality of a selection strategy for the solid-phase construction and evaluation of large libraries of BLM analogues having altered properties.
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Solid-phase synthesis of bleomycin A5 and three monosaccharide analogues: Exploring the role of the carbohydrate moiety in RNA cleavage
Craig J. Thomas,Alexander O. Chizhov,Christopher J. Leitheiser,Michael J. Rishel,Kazuhide Konishi,Zhi Fu Tao,Sidney M. Hecht +6 more
TL;DR: The relatively facile solid-phase synthesis of bleomycin A5 and each of the carbohydrate analogues constitutes an important advance in the continuing mechanistic studies ofBleomycin.
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