Carsten Skarke
University of Pennsylvania
61 Papers
530 Citations
Carsten Skarke is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 26, co-authored 52 publications. Previous affiliations of Carsten Skarke include Goethe University Frankfurt & University of Göttingen.
Chat about Author
Papers
Genetic predictors of the clinical response to opioid analgesics: Clinical utility and future perspectives
TL;DR: This review uses a candidate gene approach to identify possible pharmacogenetic modulators of opioid therapy, and discusses these modulators together with demonstrated genetic causes for the variability in clinical effects of opioids.
245
Analgesic effects of morphine and morphine-6-glucuronide in a transcutaneous electrical pain model in healthy volunteers
TL;DR: The objective was to quantify the extent and time course of the effects of morphine‐6‐glucuronide and morphine on pain threshold, pain tolerance, pupil diameter, and side effects.
232
The polymorphism A118G of the human mu-opioid receptor gene decreases the pupil constrictory effect of morphine-6-glucuronide but not that of morphine
TL;DR: The A118G SNP in the mu-receptor gene significantly reduces the potency of M6G in humans, and the concentration-response relationship of morphine was not affected by this specific SNP.
214
Enhanced absorption of boswellic acids by a lecithin delivery form (Phytosome(®)) of Boswellia extract.
Jan Hüsch,Janine Bohnet,Gert Fricker,Carsten Skarke,Christian Artaria,Giovanni Appendino,Manfred Schubert-Zsilavecz,Mona Abdel-Tawab +7 more
TL;DR: The increased systemic availability of BAs and the improved tissue distribution, qualify Casperome™ for further clinical development to fully exploit the clinical potential of BE.
136
Fibroblast growth factor 21 (FGF21) is robustly induced by ethanol and has a protective role in ethanol associated liver injury.
Bhavna N. Desai,Garima Singhal,Mikiko Watanabe,Darko Stevanovic,Thomas Lundasen,ffolliott M. Fisher,Marie L. Mather,Hilde Vardeh,Nicholas Douris,Andrew C. Adams,Imad Nasser,Garret A. FitzGerald,Jeffrey S. Flier,Carsten Skarke,Eleftheria Maratos-Flier +14 more
TL;DR: Acute or binge ethanol consumption significantly increases circulating FGF21 levels in both humans and mice, and suggests that FGF 21 protects against long term ethanol induced hepatic damage and may attenuate progression of alcoholic liver disease.
128