Carsten Rudolph
Ludwig Maximilian University of Munich
120 Papers
1K Citations
Carsten Rudolph is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Gene delivery & Transfection. The author has an hindex of 39, co-authored 120 publications. Previous affiliations of Carsten Rudolph include Shire plc & Technische Universität München.
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Papers
Expression of therapeutic proteins after delivery of chemically modified mRNA in mice
Michael S. D. Kormann,Günther Hasenpusch,Manish K. Aneja,Gabriela Nica,Andreas W. Flemmer,Susanne Herber-Jonat,Marceline Huppmann,Lauren Mays,Marta C Illenyi,Andrea Schams,Matthias Griese,Iris Bittmann,Rupert Handgretinger,Dominik Hartl,Joseph Rosenecker,Carsten Rudolph +15 more
TL;DR: In a mouse model of a lethal congenital lung disease caused by a lack of surfactant protein B (SP-B), twice weekly local application of an aerosol of modified SP-B mRNA to the lung restored 71% of the wild-type SP- B expression, and treated mice survived until the predetermined end of the study after 28 days.
911
Targeted delivery of magnetic aerosol droplets to the lung
Petra Dames,Petra Dames,Bernhard Gleich,Andreas W. Flemmer,Kerstin Hajek,Nicole Seidl,Frank Wiekhorst,Dietmar Eberbeck,Iris Bittmann,Christian Bergemann,Thomas Weyh,Lutz Trahms,Joseph Rosenecker,Carsten Rudolph,Carsten Rudolph +14 more
TL;DR: It is shown theoretically by computer-aided simulation, and for the first time experimentally in mice, that targeted aerosol delivery to the lung can be achieved with aerosol droplets comprising superparamagnetic iron oxide nanoparticles—so-called nanomagnetosols—in combination with a target-directed magnetic gradient field.
403
Insights into the mechanism of magnetofection using PEI‐based magnetofectins for gene transfer
Stephanie Huth,James Lausier,Soeren W. Gersting,Carsten Rudolph,Christian Plank,Ulrich Welsch,Joseph Rosenecker +6 more
TL;DR: Gene delivery by the use of magnetic forces, so‐called magnetofection, has been shown to enhance transfection efficiency of viral and non‐viral systems up to several‐hundred‐fold.
305
Oligomers of the arginine-rich motif of the HIV-1 TAT protein are capable of transferring plasmid DNA into cells
Carsten Rudolph,Christian Plank,James Lausier,Ulrike Schillinger,Rainer H. Müller,Joseph Rosenecker +5 more
TL;DR: Oligomers of the TAT-(47–57) peptide compact plasmid DNA to nanometric particles and stabilize DNA toward nuclease degradation are shown to help enhance gene transfer in proliferating cells.
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