Caroline Heß
4 Papers
Caroline Heß is an academic researcher. The author has contributed to research in topics: Gene & Cancer research. The author has co-authored 2 publications.
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Papers
MAPK inhibitor sensitivity scores predict sensitivity driven by the immune infiltration in pediatric low-grade gliomas
Romain Sigaud,Thomas J. Albert,Caroline Heß,Thomas Hielscher,Nadine Winkler,Daniela Kocher,Carolin Walter,Daniel Münter,Florian Selt,Diren Usta,Jonas Ecker,Angela Brentrup,Martin Hasselblatt,Christian Thomas,Julian Varghese,David Capper,Ulrich-Wilhelm Thomale,Pablo Hernáiz Driever,Michèle Simon,Svea Horn,Nina A Herz,Arend Koch,Felix Sahm,Stefan Hamelmann,Augusto Faria-Andrade,Nada Jabado,Martin U. Schuhmann,Antoinette Y. N. Schouten-van Meeteren,Eelco W. Hoving,Tilman Brummer,Cornelis M. van Tilburg,Stefan M. Pfister,Olaf Witt,David T. Jones,Kornelius Kerl,Till Milde +35 more
TL;DR: A role for microglia in the response to MAPKi is supported and the MSSs represent predictive tools for the stratification of pLGG patients and should be prospectively validated in clinical trials.
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Lgg-02. drug-class specific gene-based mapk sensitivity scores (mss) predict sensitivity to mapk inhibitors and identify immune infiltration as putative target in pediatric low-grade gliomas
Romain Sigaud,Thomas J. Albert,Caroline Heß,Thomas Hielscher,Nadine Winkler,Carolin Walter,Florian Selt,Diren Usta,Jonas Ecker,Angela Brentrup,Martin Hasselblatt,Christian Thomas,Julian Varghese,David Capper,Ulrich-Wilhelm Thomale,Pablo Hernáiz Driever,Michèle Simon,Svea Horn,Nina A Herz,Arend Koch,Felix Sahm,Stefan Hamelmann,Augusto Faria Andrade,Nada Jabado,Antoinette Y. N. Schouten-van Meeteren,Eelco W. Hoving,Tilman Brummer,Cornelis M. van Tilburg,Stefan M. Pfister,Olaf Witt,David T. Jones,Kornelius Kerl,Till Milde +32 more
TL;DR: In this paper , gene-expression-based MAPKi sensitivity scores (MSSs) were generated for each MAPK inhibitor (BRAFi, MEKi, ERKi), based on MAPK-related genes differentially regulated between MAPK sensitive and non-sensitive cell lines from the Genomics of Drug Sensitivity in Cancer (GDSC) dataset.
LGG-26. Predicting MAPK inhibitor sensitivity in pediatric low-grade gliomas with novel gene expression-derived signatures
Romain Sigaud,Caroline Heß,Thomas Hielscher,Nadine Winkler,Florian Selt,Daniela Kocher,Leo Nonnenbroich,Diren Usta,Alexander C Sommerkamp,Isabel Büdenbender,David Capper,Ulrich-Wilhelm Thomale,Pablo Hernáiz Driever,Michè le Simon,Arend Koch,Nada Jabado,Augusto Faria Andrade,Netteke Schouten-van Meeteren,Eelco W. Hoving,Cornelis M. van Tilburg,Stefan M. Pfister,Olaf Witt,David T. Jones,Till Milde +23 more
TL;DR: A strong positive correlation between MAPKi sensitivity signature scores and the predicted immune cell infiltration rate as determined by the ESTIMATE score is observed, which could support a role of immunecell infiltration in the response toMAPKi in pLGG, warranting further validation.
Monoclonal Antibodies: What the Diagnostic Neuroradiologist Needs to Know.
R. Alsufayan,Caroline Heß,T. Krings +2 more
- 17 Aug 2023
TL;DR: It is important for radiologists, neuroradiologists, and neurologists to be aware of these drugs and their possible different imaging-related manifestations, including expected and adverse effects of these novel drugs, to assist in the diagnosis of these conditions.