Carol Readhead
California Institute of Technology
60 Papers
742 Citations
Carol Readhead is an academic researcher from California Institute of Technology. The author has contributed to research in topics: Transgene & Myelin. The author has an hindex of 25, co-authored 59 publications. Previous affiliations of Carol Readhead include Cedars-Sinai Medical Center & Boston Children's Hospital.
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Papers
Premature arrest of myelin formation in transgenic mice with increased proteolipid protein gene dosage.
TL;DR: Dysmyelination of PLP transgenic mice provides experimental evidence that Pelizaeus-Merzbacher disease, previously associated with a partial duplication of the human X chromosome, can be caused by doubling of the PLP gene dosage.
299
Mapping a multiplexed zoo of mRNA expression
Harry M. T. Choi,Colby R. Calvert,Naeem Husain,David Huss,Julius C. Barsi,Benjamin E. Deverman,Ryan C. Hunter,Mihoko Kato,S. Melanie Lee,Anna C. T. Abelin,Adam Z. Rosenthal,Omar S. Akbari,Yuwei Li,Yuwei Li,Bruce A. Hay,Paul W. Sternberg,Paul H. Patterson,Eric H. Davidson,Sarkis K. Mazmanian,David A. Prober,Matt van de Rijn,Jared R. Leadbetter,Dianne K. Newman,Carol Readhead,Carol Readhead,Marianne E. Bronner,Barbara J. Wold,Rusty Lansford,Tatjana Sauka-Spengler,Scott E. Fraser,Niles A. Pierce +30 more
TL;DR: Multiplexed in situ hybridisation chain reaction allows visualisation of multiple mRNAs in a single sample with subcellular resolution, providing an incisive tool for the study of interlaced and overlapping expression patterns, with implications for research communities across the biological sciences.
Myelin deficient mice: Expression of myelin basic protein and generation of mice with varying levels of myelin
Brian Popko,Brian Popko,Carmie Puckett,Carmie Puckett,Eric Lai,Eric Lai,H. David Shine,Carol Readhead,Carol Readhead,Naoki Takahashi,Naoki Takahashi,Stephen W. Hunt,Stephen W. Hunt,Richard L. Sidman,Leroy Hood,Leroy Hood +15 more
TL;DR: It is demonstrated in mld mice that the gene encoding myelin basic protein (MBP) is expressed at decreased levels and on an abnormal temporal schedule relative to the wild-type gene.
212
The dysmyelinating mouse mutations shiverer (shi) and myelin deficient (shimld).
Carol Readhead,Leroy Hood +1 more
TL;DR: Myelin deficient shimld/shimld is allelic to shiverer (shi/shi) but the mutant mouse is less severely affected, and transgenic shicher mice with the wild-type MBP transgene have normal phenotypes.
152
Visualizing diffusion tensor images of the mouse spinal cord
David H. Laidlaw,Eric T. Ahrens,David Kremers,Matthew J. Avalos,Russell E. Jacobs,Carol Readhead +5 more
- 18 Oct 1998
TL;DR: The visualizations show significant differences between spinal cords from mice suffering from experimental allergic encephalomyelitis and spinal cord from wild-type mice and suggest that the new non-invasive imaging methodology and visualization of the results could have early diagnostic value for neurodegenerative diseases.