C Hayford
Charité
6 Papers
66 Citations
C Hayford is an academic researcher from Charité. The author has contributed to research in topics: Inflammation & Inflammatory bowel disease. The author has an hindex of 6, co-authored 6 publications. Previous affiliations of C Hayford include Imperial College London & King's College London.
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Papers
Programmed death ligand-1 over-expression correlates with malignancy and contributes to immune regulation in ovarian cancer
Christian J. Maine,Nor Haslinda Abdul Aziz,Jayanta Chatterjee,C Hayford,Nancy Brewig,Lynsey M. Whilding,Andrew J.T. George,Andrew J.T. George,Sadaf Ghaem-Maghami +8 more
TL;DR: Overall, data based on samples obtained from women with ovarian cancer is presented, suggesting the PD-1 pathway may be used as a reliable diagnostic marker in OC, as well as a viable target for use withPD-1/PD-L1-directed antibody immunotherapy.
118
Essential role of IRF4 and MYC signaling for survival of anaplastic large cell lymphoma
Andre Weilemann,Michael Grau,Tabea Erdmann,Tabea Erdmann,Olaf Merkel,Ulduz Sobhiafshar,Ioannis Anagnostopoulos,Michael Hummel,Antje Siegert,C Hayford,Hannelore Madle,Hannelore Madle,Brigitte Wollert-Wulf,Brigitte Wollert-Wulf,Iduna Fichtner,Bernd Dörken,Bernd Dörken,Stephan Dirnhofer,Stephan Mathas,Stephan Mathas,Martin Janz,Martin Janz,N. C. Tolga Emre,Andreas Rosenwald,German Ott,Peter Lenz,Alexandar Tzankov,Georg Lenz,Georg Lenz +28 more
TL;DR: It is demonstrated that ALCLs are dependent on IRF4 and MYC signaling and that MYC may represent a promising target for future therapies, as both knockdown of MYC and pharmacologic inhibition ofMYC signaling were toxic to ALCL cell lines.
93
Dasatinib is a potent inhibitor of tumour-associated macrophages, osteoclasts and the FMS receptor.
TL;DR: Dasatinib is a potent inhibitor of tumour-associated macrophages, osteoclasts and the FMS receptor and its application in oncology is still under investigation.
70
CD44v7 ligation downregulates the inflammatory immune response in Crohn's disease patients by apoptosis induction in mononuclear cells from the lamina propria
Ute Hoffmann,Katja Heilmann,C Hayford,Andreas Stallmach,U Wahnschaffe,Martin Zeitz,U Günthert,Bianca M. Wittig +7 more
TL;DR: It is shown that CD44v7 expression was upregulated upon CD40 ligation in human mononuclear cells, and this findings point to a novel mechanism of apoptosis induction in CD patients mediated by CD 44v7 ligation.
Expression of Human Tissue Factor Pathway Inhibitor on Vascular Smooth Muscle Cells Inhibits Secretion of Macrophage Migration Inhibitory Factor and Attenuates Atherosclerosis in ApoE−/− Mice
Daxin Chen,Min Xia,C Hayford,El Li Tham,Vikki Semik,Stuart Hurst,Ying Chen,Henry H. Tam,Jun Pan,Yucheng Wang,Xiaojin Tan,Hui-Yao Lan,Huahao Shen,Vijay V. Kakkar,Qingbo Xu,John H. McVey,Anthony Dorling +16 more
TL;DR: The data indicate that tissue factor plays a hitherto unreported role in the generation of MIF by SMCs in Atherosclerosis-prone ApoE−/− mice, inhibition of which significantly prevents the development of atherosclerosis, through inhibition of leukocyte recruitment.