C. Grappone
University of Florence
19 Papers
607 Citations
C. Grappone is an academic researcher from University of Florence. The author has contributed to research in topics: Receptor & Hepatic stellate cell. The author has an hindex of 12, co-authored 17 publications.
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Papers
Endothelin 1 is overexpressed in human cirrhotic liver and exerts multiple effects on activated hepatic stellate cells
Massimo Pinzani,Stefano Milani,R. De Franco,C. Grappone,Alessandra Caligiuri,A. Gentilini,C. Tosti-Guerra,Mario Maggi,Paola Failli,C. Ruocco,Paolo Gentilini +10 more
TL;DR: Endothelin (ET) 1 may act as a paracrine and autocrine factor for activated HSC and contribute to the increased resistance to portal flow in cirrhotic liver.
403
•Journal Article
Increased expression of monocyte chemotactic protein-1 during active hepatic fibrogenesis: correlation with monocyte infiltration.
Fabio Marra,Raffaella DeFranco,C. Grappone,Stefano Milani,Sabrina Pastacaldi,Massimo Pinzani,Roberto Giulio Romanelli,Giacomo Laffi,Paolo Gentilini +8 more
TL;DR: Comparison of serial sections of liver biopsies from patients with various degrees of necro-inflammatory activity showed that infiltration of the portal tracts with monocytes/macrophages is directly correlated with the expression of MCP-1.
317
•Journal Article
Expression of platelet-derived growth factor and its receptors in normal human liver and during active hepatic fibrogenesis.
Massimo Pinzani,Stefano Milani,Hermann Herbst,Raffaella DeFranco,C. Grappone,A. Gentilini,Alessandra Caligiuri,Giulia Pellegrini,Dac Vinh Ngo,Roberto Giulio Romanelli,Paolo Gentilini +10 more
TL;DR: Evidence for a functional involvement of PDGF/PDGF-R in liver fibrogenesis is provided, greatly support the results of previous in vitro studies and direct attention toward pharmacological strategies able to affect the series of signaling events arising from the autophosphorylation of PD GF-R subunits.
303
•Journal Article
Differential expression of matrix-metalloproteinase-1 and -2 genes in normal and fibrotic human liver.
Stefano Milani,Hermann Herbst,Detlef Schuppan,C. Grappone,Giulia Pellegrini,Massimo Pinzani,Alessandro Casini,Antonio Calabrò,G. Ciancio,Federico M. Stefanini +9 more
TL;DR: Along with de novo fibrogenesis and possibly influenced by transforming growth factor-beta 1, expression of MMP-2 in the absence of M MP-1 expression may be responsible for the quantitative and qualitative changes of extracellular matrix observed in chronic liver disease.
266
Expression of platelet-derived growth factor receptors in normal and diseased human kidney. An immunohistochemistry and in situ hybridization study.
Loreto Gesualdo,S. Di Paolo,Stefano Milani,Massimo Pinzani,C. Grappone,Elena Ranieri,G Pannarale,Francesco Paolo Schena +7 more
TL;DR: PDGF-beta receptor activation is established as a candidate for driving glomerular and interstitial proliferation and, probably, expansion of extracellular matrix in proliferative glomerulonephritis, while the role of PDGF-alpha receptor activation at the renal level remains to be elucidated.