C. Barbot
University of Bordeaux
11 Papers
161 Citations
C. Barbot is an academic researcher from University of Bordeaux. The author has contributed to research in topics: Progenitor cell & Bone marrow. The author has an hindex of 7, co-authored 11 publications.
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Papers
Gene transfer of the uroporphyrinogen III synthase cDNA into haematopoietic progenitor cells in view of a future gene therapy in congenital erythropoietic porphyria
Frédéric Mazurier,François Moreau-Gaudry,Stéphanie Salesse,C. Barbot,Cécile Ged,Josy Reiffers,H. de Verneuil +6 more
TL;DR: In this paper, retroviral transfer in deficient human fibroblasts, immortalized lymphoblasts as well as bone marrow cells, and obtained a complete restoration of the enzymatic activity and full metabolic correction.
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Correction of the enzyme defect in cultured congenital erythropoietic porphyria disease cells by retrovirus-mediated gene transfer.
François Moreau-Gaudry,Cécile Ged,C. Barbot,Frédéric Mazurier,Jean-Michel Boiron,M. Bensidhoum,Josy Reiffers,H. de Verneuil +7 more
TL;DR: The results demonstrate the potential usefulness of somatic gene therapy for the treatment of CEP and construct two retroviral vectors, LUSN and pMFG-US, containing a full-length human cDNA for UROIIIS.
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•Journal Article
Cytokine-mediated expansion of 5-fu-resistant peripheral blood stem cells
Alison M. Rice,Jean-Michel Boiron,C. Barbot,Maryse Dupouy,N Dubosc-Marchenay,Patrice Dumain,Francis Lacombe,Josy Reiffers +7 more
TL;DR: The results suggest that PBSC contain a primitive stem cell population with an enhanced expansion capacity that is identified by 5-FU resistance, which may then be suitable for a number of clinical applications.
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5-fluorouracil permits access to a primitive subpopulation of peripheral blood stem cells.
Alison M. Rice,C. Barbot,Francis Lacombe,N Dubosc-Marchenay,Gerald Marit,F. Hau,Jean-Michel Boiron,Josy Reiffers +7 more
TL;DR: It is demonstrated that PBSC contain a heterogenous mixture of hematopoietic progenitors and that incubation with 25 μg/ml 5‐FU permits access to a quiescent primitive stem cell population that requires a combination of synergistic growth factors for the development of morphologically identifiable clonogenic elements at day 21 of culture.
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