C. Adrian Shuttleworth
University of Manchester
19 Papers
169 Citations
C. Adrian Shuttleworth is an academic researcher from University of Manchester. The author has contributed to research in topics: Fibrillin & Microfibril. The author has an hindex of 12, co-authored 19 publications.
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Papers
The Tight Skin Mouse: Demonstration of Mutant Fibrillin-1 Production and Assembly into Abnormal Microfibrils
Cay M. Kielty,Michael Raghunath,Linda D. Siracusa,Michael J. Sherratt,Reiner Peters,C. Adrian Shuttleworth,Sergio A. Jimenez +6 more
TL;DR: In this article, the consequences of the tight skin (Tsk) mutation for fibrillin-containing microfibrils have been examined, and the presence of a structurally abnormal population of micro fibrils in Tsk/+ skin was unequivocally demonstrated after calcium chelation and in denaturating conditions.
Fibrillin-containing microfibrils: Structure and function in health and disease
TL;DR: This review examines current understanding of the expression and assembly of fibrillin and describes new approaches which are now being applied to elucidate the many outstanding structural, organisational and functional aspects of thefibrillin-containing microfibrils.
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Three new α-chains of collagen from a non-basement membrane source
TL;DR: Three new collagen α chains have been isolated from synovial membrane, gingiva and skin and contain no detectable 3-hydroxyproline, are highly glycosylated and all sugar residues are present as the disaccharides.
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Applying elastic fibre biology in vascular tissue engineering.
Cay M. Kielty,Simon Stephan,Michael J. Sherratt,Matthew R. Williamson,C. Adrian Shuttleworth +4 more
TL;DR: This review addresses physiological elastic fibre assembly and contributions to vessel structure and function, and how elastic fibre biology is now being exploited in small diameter vascular graft design.
Fibrillin: evidence that chondroitin sulphate proteoglycans are components of microfibrils and associate with newly synthesised monomers
TL;DR: It is indicated that chondroitin sulphate proteoglycans associate with fibrillin and contribute to microfibril assembly, which has major implications for microFibril function in health and disease.
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