Brigitte Hayek
University of Vienna
14 Papers
579 Citations
Brigitte Hayek is an academic researcher from University of Vienna. The author has contributed to research in topics: Immunoglobulin E & Allergen. The author has an hindex of 9, co-authored 14 publications. Previous affiliations of Brigitte Hayek include Vienna General Hospital.
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Papers
Vaccination with genetically engineered allergens prevents progression of allergic disease
Verena Niederberger,Friedrich Horak,Susanne Vrtala,Susanne Spitzauer,Maria Theresa Krauth,Peter Valent,Jürgen Reisinger,M. Pelzmann,Brigitte Hayek,M. Kronqvist,Guro Gafvelin,Hans Grönlund,Ashok Purohit,Roland Suck,H. Fiebig,Oliver Cromwell,Gabrielle Pauli,M. van Hage-Hamsten,Rudolf Valenta +18 more
TL;DR: Rises of allergen-specific IgE induced by seasonal birch pollen exposure were significantly reduced in vaccinated patients, and vaccination with genetically engineered allergenic derivatives is a therapy for allergy that not only ameliorates allergic reactions but also reduces the IgE production underlying the disease.
Molecular and Immunological Characterization of Arginine Kinase from the Indianmeal Moth, Plodia interpunctella, a Novel Cross-Reactive Invertebrate Pan-Allergen
Marina Binder,Vera Mahler,Brigitte Hayek,Wolfgang R. Sperr,Matthias Schöller,Sabine Prozell,Gerhard Wiedermann,Peter Valent,Rudolf Valenta,Michael Duchêne +9 more
TL;DR: The results indicate that arginine kinases represent a new class of cross-reactive invertebrate pan-allergens and may be used to identify a group of polysensitized indoor allergic patients and for immunotherapy of these individuals.
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Different IgE Reactivity Profiles in Birch Pollen-Sensitive Patients from Six European Populations Revealed by Recombinant Allergens: An Imprint of Local Sensitization
Robert Movérare,Kerstin Westritschnig,Margareta Svensson,Brigitte Hayek,Mats Bende,Gabrielle Pauli,Ritva Sorva,Tari Haahtela,Rudolf Valenta,Lena Elfman +9 more
TL;DR: In this in vitro study, component-resolved allergy diagnosis with recombinant allergens reveals that the IgE reactivity profiles to individual birch pollen allergens vary between European populations, which may be explained by sensitization to different allergen sources.
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Calcium–Binding Allergens: From Plants to Man
Rudolf Valenta,Brigitte Hayek,Susanne Seiberler,Agnes Bugajska-Schretter,Verena Niederberger,Anna Twardosz,Susanne Natter,Luca Vangelista,Annalisa Pastore,Susanne Spitzauer,Dietrich Kraft +10 more
TL;DR: Calcium–binding proteins contain a variable number of motifs, termed EF–hands, which consist of two perpendicularly placed α–helices and an interhelical loop forming a single calcium–binding site that greatly depend on the presence of protein–bound calcium ions.
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Calcium-dependent immunoglobulin E recognition of the apo- and calcium-bound form of a cross-reactive two EF-hand timothy grass pollen allergen, Phl p 7
Verena Niederberger,Brigitte Hayek,Susanne Vrtala,Sylvia Laffer,Anna Twardosz,Luca Vangelista,Wolfgang R. Sperr,Peter Valent,Helmut Rumpold,Dietrich Kraft,Klaus Ehrenberger,Rudolf Valenta,Susanne Spitzauer +12 more
TL;DR: Recombinant Phl p 7 may be used for diagnosis and perhaps treatment of a group of patients who suffer from allergy to pollens of many unrelated plant species and represents an example for the conformation‐dependent IgE recognition of an allergen.
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