Brennan Harmon
Children's National Medical Center
41 Papers
288 Citations
Brennan Harmon is an academic researcher from Children's National Medical Center. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 15, co-authored 28 publications.
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Papers
Age-Associated Methylation Suppresses SPRY1, Leading to a Failure of Re-quiescence and Loss of the Reserve Stem Cell Pool in Elderly Muscle
Anne Bigot,William Duddy,Zamalou Gisele Ouandaogo,Elisa Negroni,Virginie Mariot,Svetlana Ghimbovschi,Brennan Harmon,Aurore Wielgosik,Camille Loiseau,Joseph M. Devaney,Julie Dumonceaux,Gillian Butler-Browne,Vincent Mouly,Stephanie Duguez +13 more
TL;DR: An impaired capacity for stem cell self-renewal in elderly muscle is demonstrated and it is proposed that suppression of SPRY1 by age-associated methylation in humans inhibits the replenishment of the muscle stem cell pool, contributing to a decreased regenerative response in old age.
121
Tissue-specific alternative splicing of TCF7L2.
Ludmila Prokunina-Olsson,Cullan Welch,Ola Hansson,Neeta Adhikari,Laura J. Scott,Nicolle Usher,Maurine Tong,Andrew G. Sprau,Amy J. Swift,Lori L. Bonnycastle,Michael R. Erdos,Zhi He,Richa Saxena,Brennan Harmon,Olga Kotova,Eric P. Hoffman,David Altshuler,Leif Groop,Michael Boehnke,Francis S. Collins,Jennifer L. Hall +20 more
TL;DR: No association between expression of TCF7L2 in eight types of human tissue samples and T2D-associated genetic variants remained significant, and a tissue-specific pattern of alternative splicing was identified.
Integrated omics endotyping of infants with respiratory syncytial virus bronchiolitis and risk of childhood asthma
Yoshihiko Raita,Marcos Pérez-Losada,Robert J. Freishtat,Brennan Harmon,Jonathan M. Mansbach,Pedro A. Piedra,Zhaozhong Zhu,Carlos A. Camargo,Kohei Hasegawa +8 more
TL;DR: Raita et al. as mentioned in this paper integrated clinical, virus, airway microbiome (species-level), transcriptome, and metabolome data of 221 infants hospitalized with RSV bronchiolitis in a multicentre prospective cohort study.
Skeletal muscle characteristics are preserved in hTERT/cdk4 human myogenic cell lines
Matthew Thorley,Stephanie Duguez,Stephanie Duguez,Emilia Maria Cristina Mazza,Sara Valsoni,Anne Bigot,Kamel Mamchaoui,Brennan Harmon,Thomas Voit,Vincent Mouly,William Duddy,William Duddy +11 more
TL;DR: Immortalization had no observed effect on the myogenic cascade or on any other cellular processes, and it was protective against the systems level effects of senescence that are observed at higher division counts of primary cells.
76
PPARα L162V underlies variation in serum triglycerides and subcutaneous fat volume in young males
Julieta Uthurralt,Heather Gordish-Dressman,Meg Bradbury,Carolina Tesi-Rocha,Joseph M. Devaney,Brennan Harmon,Erica K.M. Reeves,Cinzia Brandoli,Barbara C. Hansen,Richard L. Seip,Paul D. Thompson,Thomas B. Price,Thomas B. Price,Theodore J. Angelopoulos,Priscilla M. Clarkson,Niall M. Moyna,Linda S. Pescatello,Paul S. Visich,Robert F. Zoeller,Paul M. Gordon,Eric P. Hoffman +20 more
TL;DR: This study suggests that the primary effect of PPARα L162V is on serum triglycerides, with downstream effects on adiposity and response to training, and shows a much larger effect of the V allele than previously reported in older and less healthy populations.