Beth Chen
National Institutes of Health
10 Papers
1 Citations
Beth Chen is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Antigen & Immunogenicity. The author has an hindex of 5, co-authored 6 publications.
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Papers
Development of a Pfs25-EPA malaria transmission blocking vaccine as a chemically conjugated nanoparticle.
Richard L. Shimp,Christopher G. Rowe,Karine Reiter,Beth Chen,Vu Nguyen,Joan Aebig,Kelly M. Rausch,Krishan Kumar,Yimin Wu,Albert J. Jin,David S. Jones,David L. Narum +11 more
TL;DR: To overcome the poor immunogenicity, processes to produce and characterize recombinant Pfs25H conjugated to a detoxified form of Pseudomonas aeruginosa exoprotein A (EPA) have been developed and used to manufacture a cGMP pilot lot for use in human clinical trials.
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Outer membrane protein complex as a carrier for malaria transmission blocking antigen Pfs230
Puthupparampil V. Scaria,Christopher G. Rowe,Beth Chen,Olga Muratova,Elizabeth R. Fischer,Emma Barnafo,Charles Anderson,Irfan Zaidi,Lynn Lambert,Bob J. Lucas,Debbie D. Nahas,David L. Narum,Patrick E. Duffy +12 more
- 08 Jul 2019
TL;DR: Researchers chemically conjugate a part of Pf230 to membrane vesicles derived from bacteria, so-called outer membrane protein complexes (OMPC), as a carrier for Pfs230, which is expressed on sexual Plasmodium stages of TBV.
Protein-protein conjugate nanoparticles for malaria antigen delivery and enhanced immunogenicity.
Puthupparampil V. Scaria,Beth Chen,Christopher G. Rowe,David S. Jones,Emma Barnafo,Elizabeth R. Fischer,Charles Anderson,Nicholas J. MacDonald,Lynn Lambert,Kelly M. Rausch,David L. Narum,Patrick E. Duffy +11 more
TL;DR: This study compared the immunogenicity of conjugates prepared by four different chemistries using different malaria antigens, and carriers such as EPA, TT and CRM197, to demonstrate the multiple options with respect to carriers and chemistries that are available for protein-protein conjugate vaccine development.
A Method for Producing Protein Nanoparticles with Applications in Vaccines
David S. Jones,Christopher G. Rowe,Beth Chen,Karine Reiter,Kelly M. Rausch,David L. Narum,Yimin Wu,Patrick E. Duffy +7 more
TL;DR: Mice vaccinated with mixed particles of Pfs25 or CSP and EPA generated significantly greater antigen-specific antibody levels compared with mice vaccinated with the respective unmodified monomeric antigens, validating the potential of antigen-EPA nanoparticles as vaccines.
Comparison of carrier proteins to conjugate malaria transmission blocking vaccine antigens, Pfs25 and Pfs230.
Puthupparampil V. Scaria,Beth Chen,Christopher G. Rowe,Nada Alani,Olga Muratova,Emma Barnafo,Lynn Lambert,Irfan Zaidi,Andrew Lees,Kelly M. Rausch,David L. Narum,Patrick E. Duffy +11 more
TL;DR: More potent carriers may augment the immunogenicity of these antigens for a more efficacious vaccine; here, a series of proteins are evaluated to identify such a carrier.
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