Barbara Podobnik
Novartis
23 Papers
59 Citations
Barbara Podobnik is an academic researcher from Novartis. The author has contributed to research in topics: Chemistry & Cochliobolus lunatus. The author has an hindex of 8, co-authored 22 publications.
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Papers
Production of Nonclassical Inclusion Bodies from Which Correctly Folded Protein Can Be Extracted
Simona Jevsevar,Vladka Gaberc-Porekar,Irena Fonda,Barbara Podobnik,Jože Grdadolnik,Viktor Menart +5 more
TL;DR: A new approach to biosynthesis at low temperature is designed, enabling the formation of “nonclassical” inclusion bodies from which correctly folded protein can be readily extracted by nondenaturing solvents or low concentrations of polarsolvents such as DMSO and nondetergent sulfobetaines.
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Antifungal activity of cinnamic acid derivatives involves inhibition of benzoate 4-hydroxylase (CYP53).
Branka Korošec,Matej Sova,Samo Turk,Nada Kraševec,Metka Novak,Ljerka Lah,Jure Stojan,Barbara Podobnik,Sabina Berne,Neja Zupanec,M. Bunc,Stanislav Gobec,Radovan Komel +12 more
TL;DR: CYP53A15, from the sorghum pathogen Cochliobolus lunatus, is involved in detoxification of benzoate, a key intermediate in aromatic compound metabolism in fungi, which is a promising drug target in fungal pathogens of other eukaryotes.
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CYP53A15 of Cochliobolus lunatus, a target for natural antifungal compounds.
Barbara Podobnik,Jure Stojan,Ljerka Lah,Nada Kraševec,Matej Seliškar,Tea Lanisnik Rizner,Damjana Rozman,Radovan Komel +7 more
TL;DR: Results suggest that CYP53A15 O-demethylation activity is important in detoxification of other antifungal substances and with the design of potent inhibitors, CYP 53 enzymes could serve as alternative antIFungal drug targets.
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•Journal Article
The Characterization and Potential use of G-CSF Dimers and their Pegylated Conjugates.
Katarina Fidler,Simona Jevsevar,Tatjana Milunović,Skrajnar S,Premzl A,Kunstelj M,Zore I,Barbara Podobnik,Mateja Kusterle,Simon Caserman,Kenig M,Smilović,Gaberc-Porekar L +12 more
TL;DR: Although significantly lower in the residual in vitro biological activity, the diPEG-Fdim conjugate exhibited pharmacokinetical (PK) and pharmacodynamical (PD) properties comparable to pegfilgrastim or even better.
14
Virtual screening yields inhibitors of novel antifungal drug target, benzoate 4-monooxygenase.
Sabina Berne,Barbara Podobnik,Neja Zupanec,Metka Novak,Nada Kraševec,Samo Turk,Branka Korošec,Ljerka Lah,Erika Šuligoj,Jure Stojan,Stanislav Gobec,Radovan Komel +11 more
TL;DR: Two parallel virtual screening protocols were employed and 3-methyl-4-(1H-pyrrol-1-yl)benzoic acid (compound 2) was selected as the best candidate for hit-to-lead follow-up in the antifungal drug discovery process.
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