In this double-blind, parallel, single-dose study, bitolterol mesylate aerosol (three sprays, 1.11 mg) and albuterol aerosol (two sprays, 180 mcg) were compared for efficacy of bronchodilation in 120 adolescent and young adult patients with moderate to severe asthma. All patients required regular medications for asthma control. None was steroid dependent. Both medications gave effective bronchodilation within 5 min with maximum effect at 30 to 60 min. Mean percent increase in forced expiratory volume in 1 sec (FEV,) over baseline was higher for bitolterol than for albuterol at all test times up to 8 hr after a dose at which time 20% mean percent increase of FEV, over baseline was still present in the bitolterol-treated patients. With albuterol mean percent increase in FEV, fell to 15% over baseline at 5 hr after a dose. Differences in FEV, increase between the two treatment groups were statistically significant at 4 to 8 hr after a dose. Patients with baseline FEV 1 p

Bitolterol and albuterol metered-dose aerosols: Comparison of two long-acting beta2-adrenergic bronchodilators for treatment of asthma

Subject Index Vol. 16 (suppl 1), 1978

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Subject Index Vol. 16 (suppl 1), 1978