Arvid Edén
University of Gothenburg
24 Papers
103 Citations
Arvid Edén is an academic researcher from University of Gothenburg. The author has contributed to research in topics: Medicine & Neopterin. The author has an hindex of 9, co-authored 17 publications. Previous affiliations of Arvid Edén include Sahlgrenska University Hospital.
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Papers
HIV-1 Viral Escape in Cerebrospinal Fluid of Subjects on Suppressive Antiretroviral Treatment
Arvid Edén,Dietmar Fuchs,Lars Hagberg,Staffan Nilsson,Serena Spudich,Bo Svennerholm,Richard W. Price,Magnus Gisslén +7 more
TL;DR: Viral escape in CSF is more common than previously reported, suggesting that low-grade central nervous system infection may continue in treated patients, and the utility of monitoring CSF responses, as new treatment combinations and strategies modify clinical practice is suggested.
Immune activation of the central nervous system is still present after >4 years of effective highly active antiretroviral therapy.
TL;DR: HAART significantly decreases intrathecal immunoactivation, but, despite effective treatment for >4 years, a substantial proportion of patients continue to show signs of macrophage/microglia activation and intratheCal immunoglobulin production in the CNS.
172
CSF biomarkers in patients with COVID-19 and neurological symptoms: A case series.
Arvid Edén,Arvid Edén,Nelly Kanberg,Nelly Kanberg,Johanna M. Gostner,Dietmar Fuchs,Lars Hagberg,Lars Hagberg,Lars Andersson,Lars Andersson,Magnus Lindh,Richard W. Price,Henrik Zetterberg,Magnus Gisslén,Magnus Gisslén +14 more
TL;DR: The authors' results in patients with COVID-19 and neurologic symptoms suggest an unusual pattern of marked CSF inflammation in which soluble markers were increased but white cell response and other immunologic features typical of CNS viral infections were absent.
146
Neurochemical signs of astrocytic and neuronal injury in acute COVID-19 normalizes during long-term follow-up.
Nelly Kanberg,Nelly Kanberg,Joel Simrén,Arvid Edén,Arvid Edén,Lars-Magnus Andersson,Lars-Magnus Andersson,Staffan Nilsson,Nicholas J. Ashton,Pär-Daniel Sundvall,Bengt Nellgård,Kaj Blennow,Kaj Blennow,Henrik Zetterberg,Magnus Gisslén,Magnus Gisslén +15 more
TL;DR: In this article, the authors investigated whether plasma biomarkers of CNS injury were associated with neurologic sequelae after coronavirus disease 2019 (COVID-19) and found no correlation between persistent neurological symptoms and CNS injury biomarkers in the acute phase.
132
Increased Intrathecal Immune Activation in Virally Suppressed HIV-1 Infected Patients with Neurocognitive Impairment
Arvid Edén,Thomas D. Marcotte,Robert K. Heaton,Staffan Nilsson,Henrik Zetterberg,Henrik Zetterberg,Dietmar Fuchs,Donald Franklin,Richard W. Price,Igor Grant,Scott Letendre,Magnus Gisslén +11 more
TL;DR: Mild HAND was associated with increased intrathecal immune activation, and the correlation between neopterin and NFL found in NCI subjects indicates an association between neurocognitive impairment, CNS inflammation and neuronal damage, suggesting that NCI despite ART may represent an active pathological process within the CNS.