Arata Takeuchi
Niigata University
25 Papers
364 Citations
Arata Takeuchi is an academic researcher from Niigata University. The author has contributed to research in topics: T cell & Immune system. The author has an hindex of 16, co-authored 22 publications. Previous affiliations of Arata Takeuchi include Chiba University.
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Papers
CD4 CTL, a Cytotoxic Subset of CD4+ T Cells, Their Differentiation and Function
Arata Takeuchi,Takashi Saito +1 more
TL;DR: Recent findings about the generation of CD4 CTL are summarized, a model with several differentiation pathways is proposed and a subset of naïve T cells that have the potential to differentiate into CD 4 CTL is detected.
The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors.
Hiromitsu Hara,Chitose Ishihara,Arata Takeuchi,Takayuki Imanishi,Liquan Xue,Stephan W. Morris,Masanori Inui,Toshiyuki Takai,Akira Shibuya,Shinobu Saijo,Yoichiro Iwakura,Naohito Ohno,Haruhiko Koseki,Hiroki Yoshida,Josef M. Penninger,Takashi Saito +15 more
TL;DR: Deletion of the gene encoding the Bcl-10 adaptor–binding partner CARD9 resulted in impaired myeloid cell activation of NF-κB signaling by several ITAM-associated receptors, and CARD9 was required for Toll-like receptor–induced activation of dendritic cells through the activation of mitogen-activated protein kinases.
364
CRTAM determines the CD4+ cytotoxic T lymphocyte lineage
Arata Takeuchi,Mohamed E.l.Sherif G.adelhaq Badr,Kosuke Miyauchi,Chitose Ishihara,Reiko Onishi,Zijin Guo,Yoshiteru Sasaki,Hiroshi Ike,Akiko Takumi,Noriko M. Tsuji,Yoshinori Murakami,Tomoya Katakai,Masato Kubo,Takashi Saito +13 more
TL;DR: It is demonstrated that CRTAM identifies CD4 T cells with cytotoxic function, and new insights into CD4+CTL development are presented.
Cutting Edge: Negative Regulation of Immune Synapse Formation by Anchoring Lipid Raft to Cytoskeleton Through Cbp-EBP50-ERM Assembly
Katsuhiko Itoh,Masahiro Sakakibara,Sho Yamasaki,Arata Takeuchi,Hisashi Arase,Masaru Miyazaki,Nobuyuki Nakajima,Masato Okada,Takashi Saito +8 more
TL;DR: Results suggest that anchoring of lipid raft to the cytoskeleton through Cbp-EBP50-ezrin-radixin-moesin assembly regulates membrane dynamism for synapse formation and T cell activation.
Bach2 maintains T cells in a naive state by suppressing effector memory-related genes
Shin Ichi Tsukumo,Midori Unno,Akihiko Muto,Arata Takeuchi,Kohei Kometani,Tomohiro Kurosaki,Kazuhiko Igarashi,Takashi Saito +7 more
TL;DR: Findings indicate that Bach2 suppresses effector memory-related genes to maintain the naive T-cell state and regulates generation of effector-memory T cells.
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