Annegret Rosemann
Boston Children's Hospital
7 Papers
67 Citations
Annegret Rosemann is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Bone marrow & Stem cell. The author has an hindex of 6, co-authored 6 publications. Previous affiliations of Annegret Rosemann include Fred Hutchinson Cancer Research Center.
Chat about Author
Papers
Immature CD34+CD19− progenitor/stem cells in TEL/AML1-positive acute lymphoblastic leukemia are genetically and functionally normal
Marc Hotfilder,Silja Röttgers,Annegret Rosemann,Heribert Jürgens,Jochen Harbott,Josef Vormoor +5 more
TL;DR: The hypothesis that the leukemia in TEL/AML1-positive childhood ALL originates in a CD19+ lymphoid progenitor is supported, eg, for purging of autologous stem cell products, flow cytometric monitoring of minimal residual disease, and targeting immunotherapy against the leukemic cell clone.
77
A high proportion of bone marrow T cells with regulatory phenotype (CD4+CD25hiFoxP3+) in Ewing sarcoma patients is associated with metastatic disease.
Peter Brinkrolf,Silke Landmeier,Bianca Altvater,Christiane Chen,Sibylle Pscherer,Annegret Rosemann,Andreas Ranft,Uta Dirksen,Heribert Juergens,Claudia Rossig +9 more
TL;DR: Investigation of the pattern of immune cell subset distribution in BM found increased BM Treg cells in patients with metastasized ES may reflect an immune escape mechanism that contributes to the development of metastatic disease.
52
Lack of expression of the chondroitin sulphate proteoglycan neuron-glial antigen 2 on candidate stem cell populations in paediatric acute myeloid leukaemia/abn(11q23) and acute lymphoblastic leukaemia/t(4;11)
J. Neudenberger,Marc Hotfilder,Annegret Rosemann,C. Langebrake,Dirk Reinhardt,Rob Pieters,André Schrauder,Martin Schrappe,Silja Röttgers,Jochen Harbott,Josef Vormoor +10 more
TL;DR: Surprisingly, in all patients these candidate stem cell populations were shown to lack expression of NG2, which hampers the clinical use of NG1 as a therapeutic target and as a sensitive marker for MRD detection.
High Metabolic Dependence on Oxidative Phosphorylation Drives Sensitivity to Metformin Treatment in MLL/AF9 Acute Myeloid Leukemia
Longlong Liu,Pradeep Kumar Patnana,X. Xie,Daria Frank,Subbaiah Chary Nimmagadda,Annegret Rosemann,Marie Liebmann,Luisa Klotz,Bertram Opalka,Cyrus Khandanpour +9 more
TL;DR: It is demonstrated that AML cell lines have high metabolic heterogeneity, and AML cells with an MLL/AF9 genotype have a high dependency on OXPHOS and could be therapeutically targeted by metformin.
High Proportions of CD4+ T Cells among Residual Bone Marrow T Cells in Childhood Acute Lymphoblastic Leukemia Are Associated with Favorable Early Responses
Imke Lustfeld,Bianca Altvater,Martina Ahlmann,Sandra Ligges,Peter Brinkrolf,Annegret Rosemann,Anja Moericke,Claudia Rossig +7 more
TL;DR: It is concluded that CD4+ non-Treg cells in leukemic bone marrow at diagnosis may have a role in early response to treatment, and the functional role of the individual T cell subsets in immune control in pediatric ALL will be established.