Anne Wolf
University of Bonn
3 Papers
Anne Wolf is an academic researcher from University of Bonn. The author has contributed to research in topics: Isometric exercise & Phosphorylation. The author has an hindex of 3, co-authored 3 publications.
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Papers
α-Hederin, but Not Hederacoside C and Hederagenin from Hedera helix, Affects the Binding Behavior, Dynamics, and Regulation of β2-Adrenergic Receptors†
Anne Sieben,Lars Prenner,Thomas Sorkalla,Anne Wolf,Daniel Jakobs,Frank Runkel,Hanns Häberlein +6 more
TL;DR: Remarkably, structure-related saponins like hederacoside C and hederagenin did not influence either the binding behavior of beta(2)AR or the intracellular cAMP level, and this receptor regulation was unaffected.
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Pre-treatment with α-hederin increases β-adrenoceptor mediated relaxation of airway smooth muscle.
TL;DR: The bronchiolytic effect of α-hederin was demonstrated by isometric tension measurements using bovine tracheal smooth muscle strips and increases isoprenaline-induced relaxation indirectly, probably by inhibiting heterologous desensitization induced by high concentrations of muscarinic ligands like methacholine.
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α-Hederin inhibits G protein-coupled receptor kinase 2-mediated phosphorylation of β2-adrenergic receptors
Janka Schulte-Michels,Anne Wolf,Stefan Aatz,Katharina Engelhard,Anne Sieben,Manuel Martinez-Osuna,Felix Häberlein,Hanns Häberlein +7 more
TL;DR: Results indicate that α-hederin acts as an indirect GRK2 inhibitor leading to a reduced homologous desensitization of β2AR-GFP in HEK293 cells.
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